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Edaravone and (+)2-camphol liniment and preparation method thereof

A technology of edaravone and camphor, which is applied to the field of edaravone and 2-camphenol liniment and its preparation, can solve problems such as damage to body cells, and achieve the effects of good curative effect, fast onset and convenient use.

Active Publication Date: 2017-05-17
NANJING SIMCERE DONGYUAN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A variety of reasons will lead to the failure of timely and effective fluid resuscitation for scalded patients, and delayed resuscitation will generate a large amount of oxygen free radicals, which will cause serious damage to the body cells

Method used

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  • Edaravone and (+)2-camphol liniment and preparation method thereof
  • Edaravone and (+)2-camphol liniment and preparation method thereof
  • Edaravone and (+)2-camphol liniment and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] This embodiment relates to a kind of edaravone and (+) 2-camphor liniment and its preparation method.

[0029] serial number Element mg / unit 1 Edaravone 80 2 (+)2-Bornyl alcohol 20 3 ethanol 40 4 Sulfite 1800 5 water Dilute to 20ml

[0030] Step (1) Take the edaravone and pulverize it, and pass through a 60-120 mesh sieve, (+) 2-camphor is pulverized through a 60-120 mesh sieve, and the cosolvent and antioxidant pass through a 40-80 mesh sieve respectively ;

[0031] Step (2) Add edaravone to ethanol, stir to dissolve it completely; add (+)-2-camphorol at room temperature, stir to dissolve it completely, and it is medicinal solution 1;

[0032] Step (3) Dissolve sodium sulfite with an appropriate amount of water, add it to the medicinal solution 1, stir evenly, and dilute the medicinal solution with water (at room temperature) to the prescribed amount.

[0033] Step (4) Qualified samples are packaged to be finished ...

Embodiment 2

[0035] This embodiment relates to a kind of edaravone and (+) 2-camphor liniment and its preparation method.

[0036] serial number Element mg / unit 1 Edaravone 800 2 (+)2-Bornyl alcohol 200 3 ethanol 200 4 Sulfite 2000 5 water Dilute to 20ml

[0037] Step (1) Take the edaravone and pulverize it, and pass through a 60-120 mesh sieve, (+) 2-camphor is pulverized through a 60-120 mesh sieve, and the cosolvent and antioxidant pass through a 40-80 mesh sieve respectively ;

[0038] Step (2) Add edaravone to ethanol, stir to dissolve it completely; add (+)-2-camphorol at room temperature, stir to dissolve it completely, and it is medicinal solution 1;

[0039] Step (3) Dissolve sodium sulfite with an appropriate amount of water, add it to the medicinal solution 1, stir evenly, and dilute the medicinal solution with water (at room temperature) to the prescribed amount.

[0040] Step (4) Qualified samples are packaged to be finish...

Embodiment 3

[0042] This embodiment relates to a kind of edaravone and (+) 2-camphor liniment and its preparation method.

[0043] serial number Element mg / unit 1 Edaravone 20 2 (+)2-Bornyl alcohol 5 3 ethanol 20 4 Sulfite 800 5 water Dilute to 20ml

[0044] Step (1) Take the edaravone and pulverize it, and pass through a 60-120 mesh sieve, (+) 2-camphor is pulverized through a 60-120 mesh sieve, and the cosolvent and antioxidant pass through a 40-80 mesh sieve respectively ;

[0045] Step (2) Add edaravone to ethanol, stir to dissolve it completely; add (+)-2-camphorol at room temperature, stir to dissolve it completely, and it is medicinal solution 1;

[0046] Step (3) Dissolve sodium sulfite with an appropriate amount of water, add it to the medicinal solution 1, stir evenly, and dilute the medicinal solution with water (at room temperature) to the prescribed amount.

[0047] Step (4) Qualified samples are packaged to be finished pr...

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Abstract

The invention provides an edaravone and (+)2-camphol liniment and a preparation method thereof. The edaravone and (+)2-camphol liniment is prepared from the following components according to weight percent: 0.1 to 4% of edaravone, 0.05 to 1% of (+)2-camphol, 0.1 to 1% of cosolvent, 4 to 10% of antioxidant and the balance of solvent. The edaravone and (+)2-camphol liniment has the advantages of simple components and convenience in preparation and use and is a drug for external use for treating scalds, and the effect of relieving swelling and pain can be achieved when the edaravone and (+)2-camphol liniment is instantly applied to scalded skin, so that the scalded skin is quickly recovered.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an edaravone and (+)2-camphorol liniment and a preparation method thereof. Background technique [0002] Scald is a post-traumatic inflammatory disease accompanied by strong inflammatory response, tissue damage and infection in local and remote tissues and organs. A variety of reasons will cause scalded patients to fail to perform fluid resuscitation in a timely and effective manner, and delayed resuscitation will generate a large amount of oxygen free radicals, which will cause serious damage to the body cells. [0003] 3-Methyl-1-phenyl-2-pyrazolin-5-one, common name: Edaravone, its structural formula: [0004] [0005] Molecular formula: C 10 h 10 N 2 O; molecular weight: 174.20 [0006] Edaravone is a free radical scavenger, which can scavenge hydroxyl free radicals, nitric oxide free radicals and ONOO - ions, inhibit the expression of inflammation-related proteins such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4152A61K47/02A61K47/22A61P17/02A61K31/045
CPCA61K9/0014A61K31/045A61K31/4152A61K47/02A61K47/22A61K2300/00
Inventor 王磊杨士豹陈荣
Owner NANJING SIMCERE DONGYUAN PHARM CO LTD
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