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Apparatus and method for synthesizing superparamagnetic microcapsule based on microfluidic technology

A superparamagnetic, microcapsule technology, applied in chemical instruments and methods, pharmaceutical instruments, laboratory containers, etc. Improve therapeutic effect and targeting efficiency, rapid response effect

Active Publication Date: 2017-05-24
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Claims
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Problems solved by technology

[0006] The purpose of the present invention is to propose a device and method for synthesizing superparamagnetic microcapsules based on microfluidic technology, aiming at the problems of low initiative and poor targeting of transport carriers in the process of targeted therapy

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  • Apparatus and method for synthesizing superparamagnetic microcapsule based on microfluidic technology
  • Apparatus and method for synthesizing superparamagnetic microcapsule based on microfluidic technology

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Embodiment Construction

[0030] See attached figure 1 , a device for synthesizing superparamagnetic microcapsules based on microfluidic technology, which includes: polydimethylsiloxane (PDMS) layer (1), glass sheet layer (2), calcium chloride solution (3), petri dish (4), lipid liquid (5), Salmonella, culture fluid, hydrogel degradation liquid mixed solution (6), magnetic alginic acid solution (7), mineral oil (8); wherein magnetic alginic acid solution (7) Contains superparamagnetic nanoparticles. The mixed solution containing Salmonella, culture solution, hydrogel degradation solution, lipid liquid and hydrogel solution containing superparamagnetic nanoparticles are respectively injected into the microfluidic chip to form a lipid solution containing mixed liquid droplets. Then, the solution is pinched again by the mineral oil liquid (8) to form a hydrogel droplet, which is immersed in the calcium chloride solution (3), and the hydrogel liquid will undergo a cross-linking reaction with the calcium c...

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Abstract

The invention discloses an apparatus and method for synthesizing a superparamagnetic microcapsule based on microfluidic technology; a polydimethylsiloxane (PDMS) microchip is used to synthesize a 'shell-core' microcapsule-like delivery carrier (in figure 1), and shell (9) is made of naturally degradable hydrogel composed of superparamagnetic nanoparticles; a microcapsule core is of liquid form covering salmonella (12) and degradation liquid (11); salmonella density and release time are controlled by studying synthetic control factors. The invention is intended to use microfluidic technology to synthesize 'shell-core' superparamagnetic microcapsule-like delivery carrier covering salmonella, the survival rate of magnetotactic salmonella during delivery is guaranteed; through quick response to an external magnetic field, three-level precision delivery and tracing detection is achieved, the therapeutic effect and targeting efficiency of salmonella for tumors are improved, the fusion of oncology and robotics is promoted, and new theory and method are provided for the therapy of advanced colorectal cancer.

Description

technical field [0001] The invention belongs to the technical field of robotic biological micromanipulation, and in particular relates to a device and method for synthesizing superparamagnetic microcapsules based on microfluidic technology. Background technique [0002] Colorectal cancer is one of the most common malignant tumors. According to the latest statistics published by the International Agency for Research on Cancer of the World Health Organization, colorectal cancer ranks third and second among common malignant tumors in men and women, respectively, with approximately 1,400,000 new cases each year. , with about 693,900 deaths. The incidence and death of colorectal cancer in my country accounted for 18.6% and 20.1% of the total number of cases in the world respectively, both ranking first, which brought great harm to society and families. Patients with early colorectal cancer can be cured by surgery, and advanced patients mainly rely on chemotherapy and targeted th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00B01L3/00
CPCA61M37/00B01L3/5027B01L2300/12Y02A50/30
Inventor 王化平石青李兴富孙韬黄强福田敏男
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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