Skin cream used for hyperplastic scar repair and preparation method for skin cream

A technology for hypertrophic scars and skin creams, which can be applied to cosmetic preparations, preparations for skin care, and medical preparations containing active ingredients, etc. Promotion and other issues, to achieve good repair effect, fast onset, good whitening effect

Active Publication Date: 2017-05-31
广东省科玮智丽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The uneven pressure of pressure therapy on the surface of uneven scars and the friction between the pressure sleeve and the scar often lead to ulceration of the scar surface. In addition, when the pressure is applied to the limbs for a long time, the venous return is affected, resulting in swelling of the extremities and other adverse phenomena.
Radiation therapy is only suitable for the prevention and treatment of small local scars. Although the effect is better, it is expensive and has relatively large side effects
The drugs used in drug therapy mainly include steroid corticosteroids and silicones, the treatment cycle is long, there are certain side effects, and the patient's medication compliance is poor
[0004] Chinese patent application CN 103495155 discloses a patch for hypertrophic scar repair, including a backing layer, a viscous polymer layer and an isolation layer bonded in sequence, and the viscous polymer layer includes viscous polymers, liposomes Penetration enhancer and scar-removing active components, scar-removing active components include γ-interferon, Va acid and Ve, through the combined action of scar-removing active components and penetration enhancers, better hypertrophic scar repair is achieved effect, but there is a large amount of γ-interferon and the problem of complicated film preparation process, which is not conducive to industrialization promotion
[0006] Therefore, when the existing hypertrophic scar treatment methods and drugs are difficult to meet the needs of patients, it is of great significance to provide a safe and effective cosmetic for the treatment and repair of hypertrophic scars, which can significantly improve patient compliance. and broad market prospects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Skin cream for hypertrophic scar repair

[0026] A skin cream for repairing hypertrophic scars, comprising the following components and parts by weight: 1 part of onion bulb extract, 0.2 part of Centella asiatica extract, 1.2 parts of β-glucan, 3 parts of catechin, recombinant 0.0008 parts of human interleukin-12, 3 parts of squalane, 2 parts of wheat germ oil, 3 parts of cetearyl glucoside, 4 parts of isopropyl myristate, 3 parts of ethylhexyl palmitate, 1 part of octyl oxycinnamate, 4 parts of glycerin, 1.4 parts of cetearyl alcohol, 1 part of propylene glycol, 0.2 parts of housefly antimicrobial peptide, 72 parts of water.

[0027] The preparation method comprises the following steps:

[0028] S1 Weigh squalane, wheat germ oil, cetearyl glucoside, isopropyl myristate, ethylhexyl palmitate, octyl methoxycinnamate and cetearyl alcohol in the first reactor , stir and heat to 82°C to obtain material A, keep it warm for later use;

[0029] S2 Weigh glycerin, ...

Embodiment 2

[0031] Example 2 Skin cream for repairing hypertrophic scars

[0032] A skin cream for repairing hypertrophic scars, comprising the following components and parts by weight: 1.5 parts of onion bulb extract, 0.4 part of Centella asiatica extract, 1.0 part of β-glucan, 2.5 parts of catechin, recombinant 0.001 parts of human interleukin-12, 4 parts of squalane, 1 part of wheat germ oil, 3 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 2.5 parts of ethylhexyl palmitate, formazan 1.4 parts of octyl oxycinnamate, 3 parts of glycerin, 2 parts of cetearyl alcohol, 0.5 parts of propylene glycol, 0.2 parts of housefly antimicrobial peptide, 75 parts of water.

[0033] The preparation method comprises the following steps:

[0034] S1 Weigh squalane, wheat germ oil, cetearyl glucoside, isopropyl myristate, ethylhexyl palmitate, octyl methoxycinnamate and cetearyl alcohol in the first reactor , stir and heat to 80°C to obtain material A, keep it warm for later use;

[0035] ...

Embodiment 3

[0037] Example 3 Skin cream for repairing hypertrophic scars

[0038] A skin cream for repairing hypertrophic scars, comprising the following components and parts by weight: 0.5 parts of onion bulb extract, 0.2 parts of Centella asiatica extract, 1.5 parts of β-glucan, 4 parts of catechin, recombinant 0.0005 parts of human interleukin-12, 2 parts of squalane, 2.6 parts of wheat germ oil, 2 parts of cetearyl glucoside, 3 parts of isopropyl myristate, 4 parts of ethylhexyl palmitate, 2 parts of octyl oxycinnamate, 5 parts of glycerin, 1 part of cetearyl alcohol, 2 parts of propylene glycol, 0.2 parts of housefly antimicrobial peptide, 70 parts of water.

[0039] The preparation method comprises the following steps:

[0040] S1 Weigh squalane, wheat germ oil, cetearyl glucoside, isopropyl myristate, ethylhexyl palmitate, octyl methoxycinnamate and cetearyl alcohol in the first reactor , stir and heat to 82°C to obtain material A, keep it warm for later use;

[0041] S2 Weigh g...

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Abstract

The invention provides skin cream used for hyperplastic scar repair. The skin cream comprises the following components in parts by weight: 0.1-2 parts of onion bulb extract, 0.01-0.5 part of centella extract, 0.1-2 parts of beta-glucan, 1-5 parts of catechin, 0.0002-0.002 part of recombinant human interleukin-12, 1-5 parts of squalane, 1-3 parts of wheatgerm oil, 2-4 parts of cetearyl glucoside, 1-5 parts of isopropyl myristate, 1-5 parts of ethylhexyl palmitate, 0.5-2 parts of octyl methoxycinnamate, 1-5 parts of glycerol, 0.5-2 parts of cetostearyl alcohol, 0.5-2 parts of propylene glycol and 70-85 parts of water. The skin cream belongs to the technical field of cosmetics, is good in safety, is free of side effect, is quick in effect taking, has good repair effect on hyperplastic scars, is good in whitening effect, is easily accepted by a patient, and has a wide market prospect.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a skin cream for repairing hypertrophic scars and a preparation method thereof. Background technique [0002] Scar formation is a normal result of wound healing after trauma. If timely and effective intervention is performed before scar formation after trauma, scar formation is expected to be avoided. Once the scar is formed, it is difficult to heal completely, and the difficulty of treatment is greater than that of prevention. Scars can be divided into normal scars and pathological scars, and pathological scars mainly include hypertrophic scars and keloids. Hypertrophic scars are often formed after burns of degree II and above. The main clinical symptoms of hypertrophic scars are that the scar lesion is higher than the surrounding normal skin, and the local texture is hard and thickened. In the early stage, it mainly manifests as pain and itching symptoms. When th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/73A61K8/64A61K8/49A61Q19/00A61Q19/02A61K38/20A61K9/06A61P17/02A61K36/8962A61K31/716A61K31/353
CPCA61K8/4926A61K8/64A61K8/73A61K8/97A61K9/06A61K31/353A61K31/716A61K36/23A61K36/8962A61K38/20A61K47/44A61Q19/00A61Q19/02A61K2300/00
Inventor 陈松彬倪彦艳刘杰森李小翠
Owner 广东省科玮智丽生物医药有限公司
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