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Vitamin A nano emulsion and preparation method thereof

A vitamin and nanoemulsion technology, applied in the directions of pharmaceutical formula, emulsion delivery, additional food elements, etc., to achieve the effects of good stability, simple and easy method, and easy control of preparation conditions

Inactive Publication Date: 2017-05-31
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a vitamin A nanoemulsion and a preparation method thereof. The preparation process of the method is simple, does not cause physical damage, and solves the problem of water solubility of vitamin A, improves the stability of vitamin A, and enables it to be used widely. Used in food, medicine, health products, cosmetics and other fields

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A vitamin A nanoemulsion, comprising 5g of vitamin A oil, 10g of emulsifier, and 1mL of double distilled water.

[0020] The concrete steps of preparing above-mentioned vitamin A nanoemulsion are as follows:

[0021] 1) Take 5g Tween 60 and 5g EL40 (polyoxyethylene hydrogenated castor oil) and mix well as emulsifier;

[0022] 2) Add 5g vitamin A oil to the emulsifier, and stir it evenly with an electric mixer at 100 rpm, as the oil phase;

[0023] 3) Continue stirring with an electric mixer at 100 rpm, and add double distilled water dropwise to the oil phase with a pipette gun, the solution gradually becomes viscous, continue to add double distilled water dropwise, and the solution becomes a clear and translucent liquid, Continue to stir for 5 minutes to obtain the vitamin A nanoemulsion. The prepared emulsion needs to be stored away from light, and the vitamin A nanoemulsion is an oil-in-water emulsion with a particle size within the range of 1-100nm.

[0024] The pr...

Embodiment 2

[0026] A vitamin A nanoemulsion, comprising 5g of vitamin A oil, 15g of emulsifier, and 1.5mL of double distilled water.

[0027] The concrete steps of preparing above-mentioned vitamin A nanoemulsion are as follows:

[0028] 1) Take 5g Tween 60 and 10g EL40 and mix them evenly as emulsifier;

[0029] 2) Add 5g vitamin A oil to the emulsifier, and stir it evenly with an electric mixer at 100 rpm, as the oil phase;

[0030] 3) Continue stirring with an electric mixer at 100 rpm, and add double distilled water dropwise to the oil phase with a pipette gun, the solution gradually becomes viscous, continue to add double distilled water dropwise, and the solution becomes a clear and translucent liquid, Continue to stir for 10 minutes to obtain the vitamin A nanoemulsion. The prepared emulsion needs to be stored away from light, and the vitamin A nanoemulsion is an oil-in-water emulsion with a particle size within the range of 1-100nm.

[0031] The prepared vitamin A nanoemulsion i...

Embodiment 3

[0033] A vitamin A nanoemulsion, comprising 5g of vitamin A oil, 25g of emulsifier, and 2.5mL of purified water.

[0034] The concrete steps of preparing above-mentioned vitamin A nanoemulsion are as follows:

[0035] 1) Mix 10g Tween 60 and 15g EL40 evenly as emulsifier;

[0036] 2) Add 5g vitamin A oil to the emulsifier, and stir it evenly with an electric mixer at 150 rpm, as the oil phase;

[0037] 3) Continue to stir with an electric mixer at 150 rpm, and add pure water drop by drop to the oil phase with a pipette gun, the solution gradually becomes viscous, continue to add pure water, the solution becomes a clear and translucent liquid, continue to stir After 15 minutes, the vitamin A nanoemulsion is obtained, and the prepared emulsion needs to be stored away from light, and the vitamin A nanoemulsion is an oil-in-water emulsion, and the particle size is in the range of 1-100nm.

[0038] The prepared vitamin A nanoemulsion is suitable for the feed industry.

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Abstract

The invention discloses a vitamin A nano emulsion and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing an emulsifier with vitamin A oil, slowly dropping water, and preparing the vitamin A nano emulsion by using a phase transformation method, wherein the particle size of the vitamin A nano emulsion is within 1-100nm. Due to preparation of the vitamin A nano emulsion, the difficulty that vitamin A is not dissolved in water can be solved, and convenience is brought to production and application of the vitamin A nano emulsion. Due to preparation of the vitamin A nano emulsion, the stability of vitamin A is also improved, and the vitamin A nano emulsion has relatively great application values in fields such as food, healthcare products and cosmetics.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a vitamin A nanoemulsion and a preparation method thereof. Background technique [0002] Vitamin A, also known as retinol, is the earliest vitamin discovered. It is a yellow viscous liquid extracted from the liver of sturgeon. It can maintain the integrity of epithelial tissue and the permeability of cell membrane, maintain normal vision, and help animals Biological functions such as reproduction and lactation, promoting the growth of young animals. Vitamin A is a fat-soluble vitamin that is insoluble in water. Its structure contains more unsaturated double bonds, which is easy to oxidize and has poor stability, which greatly affects the absorption and utilization of vitamin A by humans and animals. [0003] Nanoemulsion, also known as microemulsion (ME), is a thermodynamically stable colloidal dispersion system formed by water phase, oil phase, surfactant ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/07A61P27/02A61P15/08A61P15/14A61P39/00A61K8/67A23L33/155A23P10/35A23K20/174A23K40/30
CPCA61K9/1075A23V2002/00A61K8/671A61K31/07A23V2200/30A23V2250/702
Inventor 毛跟年曹晴许牡丹黄萌周丹马可纯贺磊周亚丽
Owner SHAANXI UNIV OF SCI & TECH
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