Radix ophiopogonis oligosaccharide slow-release tablet and preparation method thereof

A technology of sustained-release tablets and oligosaccharides, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of large fluctuations in blood drug concentration, short half-life, and frequent medication , to achieve the effect of ensuring curative effect, simple preparation process, and reducing excessive blood drug concentration

Inactive Publication Date: 2017-05-31
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the technical problems such as large fluctuations in blood drug concentration and many times of taking medicine caused by the short half-life of ordinary tablets, and provide a kind of Ophiopogon oligosaccharides that can improve the drug compliance of patients and are more suitable for treating patients with diabetes mellitus for a long time. Sustained Release Tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] 1. Preparation of Ophiopogon japonicus oligosaccharides: Cut the medicinal material of Ophiopogon japonicus into pieces, reflux with 10 times the volume of 95% ethanol for 2 hours and then filter, discard the filtrate, evaporate to dryness with 95% ethanol with the medicinal material, add 10 times the volume of pure water to extract in a 100°C water bath Once, filter with suction, collect the filtrate and concentrate under reduced pressure to a density of 1.2g / ml, add 80% ethanol, let it stand for 12 hours, discard the ethanol solution after the sugar is precipitated, wash with absolute ethanol, anhydrous ether, and acetone respectively, Dry the precipitate at 55°C to obtain crude oligosaccharides. Dissolve crude oligosaccharides in water at a concentration of centrifugation to remove precipitation, use Sephadex G-75 chromatography column, elute with distilled water, detect with anthrone-sulfuric acid method, collect, combine elution peaks, and freeze-dry to obtain Ophio...

Embodiment 2

[0018] 1. The preparation of Ophiopogon japonicus oligosaccharides is the same as in Example 1.

[0019] 2. Preparation of sustained-release tablets

[0020] Formula: Ophiopogon japonicus oligosaccharide 100g, hydroxypropyl methylcellulose 100g, carboxyethyl cellulose 20g, lactose 10g, starch 20g, magnesium stearate 0.75g, micropowder silica gel 0.75g.

[0021] Preparation method: Mix the above materials evenly, granulate with 95% ethanol, dry, add lubricant and compress into tablets. 1000 tablets are prepared. After release measurement, the results showed that the sustained-release tablet released 10-30%, 30-60%, and 80% of the labeled amount in 2 hours, 4 hours, and 8 hours, respectively, meeting the release requirements of sustained-release preparations.

Embodiment 3

[0023] 1, the preparation of Ophiopogon japonicus oligosaccharide is identical with embodiment 1

[0024] 2. Preparation of sustained-release tablets

[0025] Recipe: Ophiopogon oligosaccharides 100g, hydroxymethylpropylcellulose 85g, sodium carboxymethylcellulose 65g, lactose 10g, microcrystalline cellulose 10g, magnesium stearate 1.5g.

[0026] Preparation method: Mix the above materials evenly, granulate with 95% ethanol, dry, add lubricant and compress into tablets. 1000 tablets are prepared. After release measurement, the results showed that the sustained-release tablet released 10-30%, 30-60%, and 80% of the labeled amount in 2 hours, 4 hours, and 8 hours, respectively, meeting the release requirements of sustained-release preparations.

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Abstract

The invention discloses a radix ophiopogonis oligosaccharide slow-release tablet and a preparation method thereof. The radix ophiopogonis oligosaccharide slow-release tablet is prepared from the following raw materials in parts by mass: 1 part of active ingredient of radix ophiopogonis, 0.5 to 1.5 parts of slow-release framework material, 0.3 to 0.6 part of filling agent, and 0.01 to 0.02 part of lubricant, wherein the slow-release framework material preferably selects hydroxypropyl methyl cellulose, sodium carboxymethylcellulose or carboxyethyl cellulose; the filling agent comprises microcrystalline cellulose, lactose or starch; the lubricant comprises magnesium stearate, superfine silica powder or talcum powder. Compared with the prior art, the radix ophiopogonis oligosaccharide slow-release tablet has the advantages that after taking, the radix ophiopogonis oligosaccharide can be effectively and stably released in a human body, so that the effective plasma concentration and time can be maintained, and the peak and valley of plasma concentration can be avoided; under the premises of ensuring therapy effect, the side effect caused by overhigh plasma concentration can be avoided; the preparation technology is simple, and the radix ophiopogonis oligosaccharide slow-release tablet is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to an Ophiopogon oligosaccharide sustained-release tablet and a preparation method thereof. Background technique [0002] Ophiopogon japonicus is the dry tuber of ophiopogon japonicas (thunb.) Ker-Gawl., a plant of the genus Ophiopogon japonicas (thunb.) Ker-Gawl. in the family Liliaceae. Flavonoids and other components. Studies have found that Ophiopogon japonicus polysaccharides have a significant hypoglycemic effect, and its hypoglycemic mechanism may be related to improving the function of damaged islet β cells, reducing β cell damage, inhibiting glycogen decomposition, and preventing intestinal absorption of glucose. At present, most of the drugs that effectively control hyperglycemia are western medicines, such as sulfonylureas, biguanides, and α-glucosidase inhibitors used in the treatment of diabetes. Although they can effectively control hyperglycemia, they hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/702A61K47/38A61P3/10
CPCA61K9/0002A61K9/2054A61K31/702A61K36/8968
Inventor 姚宏亮苏薇薇张伟健王永刚李沛波林爱华吴忠彭维
Owner SUN YAT SEN UNIV
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