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A kind of montelukast sodium tablet

A technology of montelukast sodium tablets and montelukast sodium, which is applied in the field of medicine, can solve problems such as instability to light, and achieve the effects of rapid dissolution, improved stability, and simple preparation process

Active Publication Date: 2018-09-18
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the prior art, in order to ensure the stability of the drug to light, only opacifiers are added and the packaging is protected from light, which does not completely solve the problem of light instability in the production process

Method used

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  • A kind of montelukast sodium tablet
  • A kind of montelukast sodium tablet
  • A kind of montelukast sodium tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Preparation Process:

[0033] Montelukast, Kollicoat IR, Polyethylene Glycol 4000 of the prescribed amount are heated to dissolve, the solution is spray-coated on the surface of the microcrystalline cellulose ball core, and then the sodium carboxymethyl starch passed through a 100-mesh sieve with the prescribed amount , magnesium stearate, and compressed into tablets.

Embodiment 2

[0035]

[0036] Preparation Process:

[0037] Montelukast, Kollicoat IR, and Polyethylene Glycol 4000 of the prescribed amount are heated to dissolve, and the solution is spray-coated on the surface of the microcrystalline cellulose ball core, and then cross-linked povidone with the prescribed amount of 100 mesh sieve , magnesium stearate, and compressed into tablets.

Embodiment 3

[0039]

[0040] Preparation Process:

[0041] Montelukast, Kollicoat IR, Polyethylene Glycol 4000 of the prescribed amount are heated to dissolve, the solution is spray-coated on the surface of the microcrystalline cellulose ball core, and then the sodium carboxymethyl starch passed through a 100-mesh sieve with the prescribed amount , magnesium stearate, and compressed into tablets.

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PUM

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Abstract

The invention belongs to the field of medicines and provides a montelukast sodium tablet. The montelukast sodium tablet is prepared by the steps: heating and melting montelukast sodium, Kollicoat IR and polyethylene glycol 4000; spraying the mixture onto the surfaces of microcrystalline cellulose pill cores; then uniformly mixing the pills with pharmaceutically common auxiliary materials; and performing tabletting to obtain the tablet. Compared with the prior art, the drug is good in stability, quick to dissolve out, simple in process and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a montelukast sodium tablet. Background technique [0002] Montelukast sodium is the sodium salt of Montelukast. Due to its unique chemical structure, its oral bioavailability, clinical efficacy and safety are superior to previous similar drugs, and it is currently the best-selling asthma drug in the world. . In 1998, the Montelukast sodium film-coated tablets of Merck & Co., Ltd. were approved by the US FDA for marketing. So far, the dosage forms of Montelukast sodium that have been on the market include granules, chewable tablets, and orally disintegrating tablets. Montelukast sodium, its chemical name is [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinoline)vinyl]phenyl-3-[ Sodium 2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetate. The chemical structure is: [0003] [0004] The Chinese patent of CN101365450A discloses the composition and prepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/32A61K31/47A61K47/10A61K47/32A61P11/06
CPCA61K9/2853A61K31/47
Inventor 张贵民郝贵周
Owner LUNAN PHARMA GROUP CORPORATION