Application of KDM1A micro-molecular inhibitor in inhibition of growth and transfer of tumor cells
A small molecule inhibitor, KDM1A technology, applied in the field of tumor treatment, can solve the problem that the mechanism of action is not very clear, and there is no report on the application of KDM1A small molecule inhibitor to tumor cells, so as to prolong life and improve the effect of treatment
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[0026] The specific implementation manners of the present invention will be further described below in conjunction with the drawings and examples. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention. The methods used in the following examples are conventional methods unless otherwise specified.
[0027] The KDM1A small molecule inhibitor of the present invention can inhibit the proliferation and metastasis of various tumor cells, including blood cancer, bone cancer, lymphoma, intestinal cancer, liver cancer, gastric cancer, lung cancer, kidney cancer, esophageal cancer, etc.; KDM1A small molecule Inhibitors include 2-PCPA, cyclopropylamine derivatives, and the like.
[0028] The following is only an example to illustrate the effect of KDM1A small molecule inhibitor 2-PCPA on the proliferation and metastasis of lung cancer cells.
[0029] 1. Culture, exp...
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