Application of KDM1A micro-molecular inhibitor in inhibition of growth and transfer of tumor cells

A small molecule inhibitor, KDM1A technology, applied in the field of tumor treatment, can solve the problem that the mechanism of action is not very clear, and there is no report on the application of KDM1A small molecule inhibitor to tumor cells, so as to prolong life and improve the effect of treatment

Inactive Publication Date: 2017-05-31
SHANGHAI PULMONARY HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its mechanism of action is still not very clear, and there is no report on the application of KDM1A small molecule inhibitors in inhibiting tumor cell growth and metastasis.

Method used

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  • Application of KDM1A micro-molecular inhibitor in inhibition of growth and transfer of tumor cells
  • Application of KDM1A micro-molecular inhibitor in inhibition of growth and transfer of tumor cells
  • Application of KDM1A micro-molecular inhibitor in inhibition of growth and transfer of tumor cells

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Embodiment Construction

[0026] The specific implementation manners of the present invention will be further described below in conjunction with the drawings and examples. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention. The methods used in the following examples are conventional methods unless otherwise specified.

[0027] The KDM1A small molecule inhibitor of the present invention can inhibit the proliferation and metastasis of various tumor cells, including blood cancer, bone cancer, lymphoma, intestinal cancer, liver cancer, gastric cancer, lung cancer, kidney cancer, esophageal cancer, etc.; KDM1A small molecule Inhibitors include 2-PCPA, cyclopropylamine derivatives, and the like.

[0028] The following is only an example to illustrate the effect of KDM1A small molecule inhibitor 2-PCPA on the proliferation and metastasis of lung cancer cells.

[0029] 1. Culture, exp...

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Abstract

The invention relates to an application of a KDM1A micro-molecular inhibitor in the inhibition of the growth and the transfer of tumor cells. The KDM1A micro-molecular inhibitor can inhibit the activity of histone demethylase KDM1A in cells and inhibit demethylation of histone H3K4me2 in order to cause up-regulation of the TIMP3 expression and promote down-regulation of extracellular MMP2 expression, inhibits the activity of JNK kinase in the cells, and effectively inhibits the invasion and the transfer of tumor cells; and the KDM1A micro-molecular inhibitor is 2-PCPA. The lung cancer cell proliferation, migration and invasion inhibition molecular mechanism of the KDM1A micro-molecular inhibitor 2-PCPA is explicated in the invention, the lung cancer treatment effect of the KDM1A micro-molecular inhibitor is researched on the basis of the molecular mechanism, the gap in the field of lung cancer treatment using an epigenetic medicine is filled, and the 2-PCPA can be used for preparing micro-molecular medicines for inhibiting the proliferation and the transfer of lung cancer cells, so the lung cancer treatment effect is improved, and the life of lung cancer patients is prolonged.

Description

technical field [0001] The invention relates to the field of tumor treatment, in particular to the application of a KDM1A small molecule inhibitor in inhibiting the growth and metastasis of tumor cells, especially the application in the preparation of drugs for inhibiting the growth and metastasis of tumor cells. Background technique [0002] Lung cancer is one of the cancers with the fastest growing rate, the largest number of patients and the highest mortality rate in the world. At present, the commonly used means of lung cancer treatment mainly include: surgical resection, radiotherapy and chemotherapy, targeted drug therapy, and the newly emerging immune cell therapy. However, since early-stage lung cancer is not easy to be detected, most patients' lung cancer is already in the middle and advanced stages when it is discovered, resulting in very limited efficacy of lung cancer treatment, and patients died due to uncontrollable recurrence and metastasis of lung cancer. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/135A61P35/00A61P35/04
CPCA61K31/135
Inventor 张鹏张帆
Owner SHANGHAI PULMONARY HOSPITAL
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