Particle size regulation method of glycine periodic crystallization process

A technology of glycine and control method, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., to achieve the effect of low operating cost, simple equipment and process

Inactive Publication Date: 2017-05-31
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Purpose of the invention: In order to solve the particle size control problem existing in the existing glycine crystallization technology, the

Method used

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  • Particle size regulation method of glycine periodic crystallization process
  • Particle size regulation method of glycine periodic crystallization process
  • Particle size regulation method of glycine periodic crystallization process

Examples

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Embodiment 1

[0025] Dissolve 30.0g of glycine in 60.0g of an aqueous solution at a temperature of 72°C, then cool the solution to 60°C, keep the temperature constant until nucleation erupts, and start to cool down at a cooling rate of 0.5°C / min after crystal growth for 30 minutes, until it drops to 15°C , after 30 minutes of crystal growth, vacuum filtration and drying obtained glycine crystals with an average particle size of 671.5 μm.

Embodiment 2

[0027] Dissolve 30.0g of glycine in 60.0g of aqueous solution at a temperature of 72°C, then lower the temperature of the solution to 54°C, keep the temperature constant until nucleation occurs, and start to cool down at a cooling rate of 0.5°C / min after growing the crystal for 30 minutes until it drops to 15°C , after 30 minutes of crystal growth, vacuum filtration and drying obtained glycine crystals with a particle size of 521.9 μm.

Embodiment 3

[0029] Dissolve 21g of glycine in 60g of aqueous solution at a temperature of 50°C, then lower the temperature of the solution to 25°C, keep the temperature constant until nucleation erupts, and start cooling at a cooling rate of 0.5°C / min after growing the crystal for 30 minutes until it drops to 10°C. After 30 minutes of crystallization, vacuum filtration and drying obtained glycine crystals with a particle size of 462.0 μm.

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Abstract

The invention provides a method of regulating a particle size of a glycine crystal product by a manner of generating seed crystals via spontaneous nucleation. According to the method, a glycine saturated aqueous solution serves as a raw material; the quantity and the particle size of crystal nucleuses in a spontaneous nucleation process are controlled by regulating a nucleation supersaturation degree; and the glycine crystal product is obtained by cooling crystallization of the crystal nucleuses generated by the spontaneous nucleation as the seed crystals. The method particularly comprises the steps of cooling, nucleation induction at a constant temperature, grain growth at the constant temperature and the cooling crystallization. The glycine crystal product in different particle sizes can be prepared by using the method.

Description

technical field [0001] The object of the present invention is to provide a method for regulating the grain size of glycine crystals in a batch crystallization process. Background technique [0002] Glycine, also known as aminoacetic acid or tyrosine, is a white monoclinic or hexagonal crystal or white crystalline powder. Glycine is an essential amino acid for the human body, and it is also an important pharmaceutical and chemical raw material. In the field of medicine, glycine, as an important pharmaceutical intermediate, can be used to prepare various effective agents such as "L-dopa", DL-phenylalanine, L-threonine, etc.; in the field of food, glycine is used as a It is an important food additive, which can improve the nutritional content of food when added to food; in the field of pesticides, glycine is an important raw material for the synthesis of high-efficiency and low-residue herbicide glyphosate; in the field of feed, adding glycine to feed can not only increase the...

Claims

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Application Information

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IPC IPC(8): C07C227/42C07C229/08
CPCC07C227/42C07C229/08
Inventor 朱亮沙作良王彦飞
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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