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A method of adding tomato juice to induce efficient accumulation of astaxanthin in Haematococcus pluvialis

A technology for Haematococcus pluvialis and tomato juice, applied in the biological field, can solve the problems of insecure yield, high equipment requirements, complicated operation, etc., and achieve the effects of increasing yield, low cost, and improving production efficiency

Active Publication Date: 2020-07-24
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned relevant patented technologies are advanced, they all involve expensive bioreactors and other professional facilities, relatively high equipment requirements, complicated technical processes, cumbersome operations, high costs, and no guarantee of output, which undoubtedly increases production costs and The difficulty of technology promotion
However, none of them involve the use of cheap and widely sourced natural substances containing astaxanthin precursors to induce the efficient accumulation of astaxanthin in Haematococcus pluvialis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Step 1. Preparation of algae liquid: use BBM medium (Hua Rucheng, 1986), culture at a temperature of 19°C, a light intensity of 2000lx, and a light-to-dark ratio of 12h / 12h, and culture until Haematococcus pluvialis cells under fluorescent lamps In the logarithmic growth phase, the cell concentration reached 2.85×10 5 Individual / mL, that is, the algae liquid obtained for induction culture;

[0015] Step 2. Inducing Haematococcus pluvialis to accumulate astaxanthin: first wash the tomatoes, sterilize the surface, peel them in a sterile environment, add equal quality sterile water to homogenate, remove the debris with four layers of sterile gauze, 10000r / min Centrifuge for 10min, take the supernatant to make tomato mother liquor for use. Add tomato juice mother liquid to the above-mentioned cultured algae liquid until the final content of tomato juice is 0.030L / L; The light-dark ratio was 24h / 0h and the compound stress condition of nutrient starvation was cultivated fo...

Embodiment 2

[0017] Step 1. Preparation of algae liquid: use BBM medium (Hua Rucheng, 1986), culture at a temperature of 21°C, a light intensity of 1800lx, and a light-to-dark ratio of 12h / 12h, and culture until Haematococcus pluvialis cells under fluorescent lamp In the logarithmic growth phase, the cell concentration reached 2.85×10 5 Individual / mL, that is, the algae liquid obtained for induction culture;

[0018] Step 2. Inducing Haematococcus pluvialis to accumulate astaxanthin: first wash the tomatoes, sterilize the surface, peel them in a sterile environment, add equal quality sterile water to homogenate, remove the debris with four layers of sterile gauze, 10000r / min Centrifuge for 10min, take the supernatant to make tomato mother liquor for use. Add tomato juice mother liquid to the above-mentioned cultured algae liquid until the final content of tomato juice is 0.029L / L; The light-dark ratio was 24h / 0h and the compound stress condition of nutrient starvation was cultivated for...

Embodiment 3

[0020] Step 1. Preparation of algae liquid: use BBM medium (Hua Rucheng, 1986), culture under the conditions of temperature 22°C, light intensity 2000lx, light-dark ratio 12h / 12h, and culture until Haematococcus pluvialis cells under fluorescent lamp In the logarithmic growth phase, the cell concentration reached 2.85×10 5 Individual / mL, that is, the algae liquid obtained for induction culture;

[0021]Step 2. First wash the tomatoes, sterilize the surface, peel them in a sterile environment, add equal quality sterile water to homogenate, remove the debris with four layers of sterile gauze, centrifuge at 10000r / min for 10min, and take the supernatant to prepare Use tomato mother liquor. Add tomato juice mother liquid to the above-mentioned cultured algae liquid until the final content of tomato juice is 0.032L / L; The culture was carried out for 18 days under the combined stress conditions of continuous fluorescent light and nutrient starvation (no nutrient salt was added dur...

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Abstract

The invention provides a method for adding tomato juice to induce Haematococcus pluvialls to efficiently accumulate astaxanthin. The following steps are adopted: (1) Preparation of algae liquid: culturing Haematococcus pluvialls cells to the logarithmic growth phase to obtain induced cultured Algae fluid; (2) Accumulation of astaxanthin: first wash and disinfect the tomatoes, peel them in a sterile environment, add equal quality sterile water to homogenate, remove debris with four layers of sterile gauze, and centrifuge at 10,000r / min for 10min , take the supernatant to make mother liquor. Add the mother liquor to the cultivated algae liquid until the final content of tomato juice is 0.025±0.005L / L algae liquid; then put the algae liquid at 28±2°C, light intensity 4800±200lx, light-dark ratio 24h / 0h and Cultured for 18±1d under the compound stress condition of nutrient starvation. The invention is simple and easy to implement, low in cost, environmentally friendly and safe, and can greatly increase the output of astaxanthin, thereby significantly improving the efficiency of producing astaxanthin by Haematococcus pluvialis.

Description

technical field [0001] The invention provides a method for inducing high-efficiency accumulation of astaxanthin in Haematococcus pluvialis by adding tomato juice, and belongs to the field of biotechnology. Background technique [0002] Natural Astaxanthin (3,3'-dihydroxy-4,4'-diketo-β,β'-carotene, C 40 h 52 o 4 ) is a red carotenoid with strong coloring and antioxidant effects, and it is widely used in medicine, cosmetics, food and aquaculture industries (Guerin M et al, 2003). Like other carotenoids, it has a long conjugated double bond, but the end of the double bond also contains unsaturated α-hydroxy ketones. This structure makes astaxanthin have some special physiological properties compared with ordinary carotenoids. function (Kamath et al, 2008). It is mainly reflected in two aspects: First, it has super strong antioxidant activity. Studies have shown that the antioxidant activity of astaxanthin is significantly higher than that of β-carotenoids (more than 10 tim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P23/00C12R1/89
CPCC12P23/00
Inventor 高政权陈国强孟春晓吴冠勋郭艳芸杜焕敏张瑞豪林彬王苗苗崔猛
Owner SHANDONG UNIV OF TECH