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Biological microscopic operating device based on visual feedback

A micro-manipulation and visual feedback technology, applied in measuring devices, material analysis by optical means, instruments, etc., can solve the problem of only continuous movement in one direction or continuous rotation, so as to simplify the operation and improve the operation. Efficiency, the effect of reducing the degree of dependence

Inactive Publication Date: 2017-06-06
BEIJING UNIV OF TECH
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  • Abstract
  • Description
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Problems solved by technology

However, this type of operation is still operated by the manual control handle. For example, to move the cell holder to the syringe for a longer distance, the hand can only move in one direction continuously or continuously rotate the operation code disc.

Method used

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  • Biological microscopic operating device based on visual feedback

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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0025] See figure 1 As shown, the present invention is a biological micromanipulation device based on visual feedback, comprising a light source (1), a microscope (9), a CCD camera (8), a left micromanipulator arm (2), and a right micromanipulator arm (6) , computer (16), XY micro-displacement platform (4), left gripper (3), right operating device (5), main controller (17), etc. Microscopic operations such as cell cutting, fusion, and injection are completed on the computer side. The left holder (3) is a suction pipe, and the right operating device (5) is an injection needle.

[0026] The CCD camera (8) is installed on the side of the microscope (9) mirror body, which is equivalent to the sensor and feedback device of the whole system, captures the image under the field of view of the microscope objective lens, and transmits it to the computer for pro...

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Abstract

The invention discloses a biological microscopic operating device based on visual feedback, and belongs to the technical field of biological operating instruments. The visual feedback based biological microscopic operating device comprises a microscopic image acquisition module, a micro-displacement platform, a micromanipulator module, a main controller and a computer. Different from the conventional operating mode, the main controller is introduced; in the whole operating process, after application of the visual-based biological microscopic operating device, all the operations can be completed on the computer side, so that the dependence degree on a professional operator is reduced, the operation is more simple, more convenient and faster, and the automation degree of microscopic operation is improved; in combination with an image processing technology, operated objects with different shapes can be matched with operating instruments, and a micro-suction pipe, a micro-injection needle and other tools can be recognized more effectively, so that the success rate of operation is improved.

Description

technical field [0001] The invention relates to the technical field of biological operation instruments, and belongs to a micromanipulation device using visual feedback, which can operate and assemble objects such as cells and chromosomes. Background technique [0002] In the field of biomedical engineering and scientific research, there are a large number of micromanipulations involving cells and chromosomes, such as single sperm injection, genetic diagnosis of single cells extracted before embryo transfer, cell separation, microinjection, chromosome cutting, etc. , These biomedical experiments all involve the observation of cells and micromanipulation. For this kind of work, not only high precision and good accuracy are required, but also short operation time and high efficiency are required. [0003] At present, micromanipulation is all done manually through micromanipulation instruments. This kind of micromanipulation equipment generally includes the following parts, sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/84
CPCG01N21/84
Inventor 余跃庆张欣张卓
Owner BEIJING UNIV OF TECH
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