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The use of protocrotaline in the preparation of anti-asthma medicine

A technology of protomonetine and asthma, applied in the field of protomonitorine in the preparation of anti-asthma drugs

Active Publication Date: 2019-10-08
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few reports on the activity of the monomeric component of protomonetine

Method used

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  • The use of protocrotaline in the preparation of anti-asthma medicine
  • The use of protocrotaline in the preparation of anti-asthma medicine
  • The use of protocrotaline in the preparation of anti-asthma medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The structural formula of the compound protobadenine used in the present invention is as follows:

[0024]

[0025] Among the present invention, the mixture preparation method of DRA and aluminum agent is as follows:

[0026] Preparation of the DRA mix :D (m) :R (m) : A (m) =1:10:1, dissolved in PBS, the concentration is 6mg / ml, mixed with the aluminum agent at a volume ratio of 1:19, and mixed on a suspension apparatus at 4°C for 4-5 hours to obtain DRA and aluminum agent mixture.

[0027] DRA mixture formulation for intranasal administration: D (m) :R (m) : A (m) =1:10:1, dissolved in PBS, the concentration is 2mg / ml.

[0028] In the present example, through animal experiments, it was found that protobarkine has a significant therapeutic effect on asthma, and the experimental methods and results are as follows:

[0029] 1 Experimental materials

[0030] 1.1 Experimental animals:

[0031] C57 / BL mice, male, weighing 20-25 g, were purchased from the Experim...

Embodiment 2

[0057] Preparation of tablets:

[0058] Take 300g of protomonetine, add appropriate amount of starch to make granules, add appropriate amount of magnesium stearate, mix well, press into 1000 tablets for oral administration, 2 times a day, 2 tablets each time.

Embodiment 3

[0060] Preparation of capsules:

[0061] Take 300g of protomonetine, add appropriate amount of diluent, mix well, divide into empty capsules and get final product. Make 1000 capsules, 2 times a day, 2 capsules each time.

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PUM

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Abstract

The invention discloses application of protostemonine in preparing an anti-asthma medicine. Asthma is DRA (Dust mite, Ragweed, Aspergillus) induced asthma or Th2 mediated asthma. The invention discloses that a main active component of radix stemonae, namely protostemonine, has a remarkable inhibition function on asthma for a first time. Test shows that the protostemonine has important values in clinical treatment on asthma, and a novel direction is provided for research of anti-asthma medicines.

Description

technical field [0001] The invention relates to the technical field of drug development and application and the field of drug therapeutics, in particular to the use of protomonetine in the preparation of anti-asthma drugs. Background technique [0002] Asthma is a chronic inflammatory disease of the airway, a complex inflammatory pathological process involving lymphocytes, dendritic cells, macrophages, mast cells, eosinophils, basophils and epithelial cells in the immune system. Under the action of allergens (allergens), patients experience airway hyperresponsive changes such as increased bronchial reactivity, increased mucus production, airway wall remodeling, and airway lumen narrowing, resulting in short-term dyspnea and wheezing and chest pressure. Asthma is a highly prevalent disease in today's society, with 1 in 10 children or 12 adults suffering from asthma. Worldwide, there are more than 300 million people with asthma, and in the United States alone, the total cost...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/55A61P11/06
Inventor 钱峰何慧琼吴亚先
Owner SHANGHAI JIAOTONG UNIV
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