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Pharmaceutical composition for treating chronic bronchitis

A technology for chronic bronchitis and a composition, applied in the field of medicine, can solve the problems of large dosage, backward dosage form, instability, etc., and achieve the effects of fast onset, symptom relief, and remarkable curative effect.

Inactive Publication Date: 2017-06-13
赵飞腾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many kinds of drugs for the treatment of acute bronchitis and acute exacerbation of chronic bronchitis, most of them have the disadvantages of backward dosage form, large dosage, slow and unstable curative effect, etc.

Method used

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  • Pharmaceutical composition for treating chronic bronchitis
  • Pharmaceutical composition for treating chronic bronchitis
  • Pharmaceutical composition for treating chronic bronchitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0015] The characterization of experimental example 1 medicine of the present invention

[0016]

[0017] 1 H NMR (500MHz, CD 3 CN) δ7.75(d, J=9.5Hz, 1H), 7.40(d, J=9.5Hz, 1H), 7.35-7.28(m, 2H), 7.27-7.20(m, 1H), 7.19-7.13( m,2H),3.80-3.47(m,6H),3.37(s,3H),3.36-3.23(m,2H),2.98-2.82(m,1H),2.73-2.60(m,1H),1.72- 1.54(m,5H),1.35-1.20(m,1H).

experiment example 2

[0018] Experimental example 2 the therapeutic effect of medicine of the present invention for chronic bronchitis

[0019] Select clean-grade male SD rats, and select 10 rats as the normal group, which are normally reared in a smoke-free environment. Other references (Zhang Liangzhi, Xie Wenying, Chang Xuehui. Effect of Airo Kechuanning Oral Liquid on the expression of LTB4 and IL-8 in rat models of chronic bronchitis[J]. Chinese Medical Journal, 2014(9):1267-1268 .) To establish a chronic bronchial rat model induced by lipopolysaccharide smoke: the rats were anesthetized with 1% pentobarbital sodium on the 1st and 14th day of the experiment, the anesthesia dose was 50 mg / kg, fixed in a supine position, and the tongue was pulled out to expose the glottis 200 μL of 0.1% lipopolysaccharide was quickly injected into the trachea with a cannula of an intravenous catheter; from the second day onwards, the rats were divided into two self-made smoke chambers of 100cm×60cm×40cm, with to...

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Abstract

The invention relates to a pharmaceutical composition for treating chronic bronchitis. The pharmaceutical composition contains a compound of the invention or pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier. The medicinal composition of the medicine is clear and controllable. The pharmaceutical composition takes effect rapidly, has remarkable curative effects, and can effectively reduce IL-13, IL-8 and TNF-alpha level of bronchoalveolar lavage fluid and lung tissue and relieve symptoms of chronic bronchitis.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating chronic bronchitis. Background technique [0002] Modern doctor trained in Western medicine thinks that bronchitis is the inflammation caused by the damage of bronchial mucosa such as virus or bacterial infection, physical, chemical stimulation or allergic reaction. Acute bronchitis generally has a rapid onset and a short course of disease, and usually improves within one to three weeks, and some cases persist and evolve into chronic bronchitis. Chronic bronchitis occurs frequently in the elderly. It is a common clinical disease and a frequently-occurring disease. If it cannot be controlled in time, it will persist repeatedly, from coughing to wheezing, and it can develop into chronic obstructive emphysema, pulmonary heart disease, etc., which seriously endanger human health. . Although the medicines for treating acute bro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/501A61P11/00
CPCA61K31/501
Inventor 赵飞腾石丽
Owner 赵飞腾
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