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Buyang huanwu gantong medicine for preventing and curing cardiovascular or cerebrovascular disease and the agent and the method for preparing the same

A technology for cardiovascular and cerebrovascular diseases and pentaside ketones, which is applied in the field of traditional Chinese medicine, can solve the problems of unstable medicinal ingredients, unfavorable promotion and clinical application of Buyang Huanwu Decoction, and ambiguity, so as to achieve clear and controllable medicinal ingredients , Prevention and treatment of heart and brain ischemic diseases, definite curative effect

Inactive Publication Date: 2007-09-19
合肥七星医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prescription contains astragalus, angelica, red peony, chuanxiong, safflower, earthworm, peach kernel, which has the effect of invigorating qi, activating blood and dredging collaterals. It is mainly used clinically for ischemic cerebrovascular disease, sequelae of hemorrhagic cerebrovascular stroke, coronary heart disease and the treatment of cor pulmonale and hyperactivity diseases, but because the decoction of the decoction is cumbersome and backward, and cannot play a first aid role, and the active ingredients are unstable, unclear, and there are many ineffective impurities, which is not conducive to the development of Buyang Huanwu Decoction. Promotion and clinical application, therefore, the development of high-standard, high-efficiency, long-acting, quick-acting formulations of effective parts of Yang Huan Wu has become a top priority

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1. The method for extracting buyanghuanpentaside ketone of the present invention:

[0036] Astragalus, Angelica, Radix Paeoniae Rubra, Chuanxiong, Safflower, Earthworm, and Peach Kernel all conform to the relevant provisions of the 2005 edition of the Chinese Pharmacopoeia. Take astragalus, angelica, chuanxiong, safflower, earthworm, and peach kernels, add 8 times the amount of water and decoct three times, 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to (temperature 70°C, vacuum number -0.08Npa) Each 1ml is equivalent to 2g of the original medicinal material. Precipitate with 95% ethanol until the alcohol content reaches 80%, refrigerate and stand for 48 hours, filter, take the filtrate to concentrate and recover ethanol, refrigerate and stand for 24 hours, filter, and the filtrate passes through the polyamide column , wash with water to remove water-soluble impurities, elute with 70% ethanol, colle...

Embodiment 2

[0038] Embodiment 2. The extraction method of buyanghuanpentaglycone of the present invention:

[0039] Take astragalus, angelica, chuanxiong, safflower, earthworm, peach kernel and add 12 times of water to decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to (temperature 70°C, vacuum number -0.08Npa) Each 1ml is equivalent to 2g of the original medicinal material. Precipitate with 95% ethanol until the alcohol content reaches 80%, refrigerate and stand for 48 hours, filter, take the filtrate to concentrate and recover ethanol, refrigerate and stand for 24 hours, filter, and the filtrate passes through the polyamide column , wash with water until there is no sugar reaction, elute with 80% ethanol, collect the eluate, filter, recover the ethanol, and concentrate until there is no alcohol smell, add 95% ethanol until the alcohol content reaches 90%, refrigerate for 24 hours, filter , recover ethanol, and...

Embodiment 3

[0041] Embodiment 3. The extraction method of buyanghuanpentaglycoside of the present invention:

[0042] Take astragalus, angelica, chuanxiong, safflower, earthworm, peach kernel and extract 8 times with alcohol three times, each time for 1.5 hours, combine the extracts, filter, and concentrate the filtrate under reduced pressure to (temperature 70°C, vacuum number -0.08Npa) Each 1ml is equivalent to 1g of the original medicinal material, add water to dilute to 1g of the original medicinal material per 4ml, refrigerate and stand for 48 hours, filter, the filtrate passes through a polyamide column, washes with water to remove water-soluble impurities, elutes with 80% ethanol, collects and washes Remove liquid, filter, recover ethanol, and concentrate until there is no alcohol smell, add 95% ethanol until the alcohol content reaches 90%, refrigerate for 24 hours, filter, recover ethanol, and concentrate under reduced pressure to dry powder.

[0043]Take Radix Paeoniae Rubra, ad...

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PUM

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Abstract

The invention discloses a yang supplementing five returning ketoside drug for preventing and treating cardio-cerebrovascular diseases, which is prepared by extracting active ingredient from raw materials of hoantchy root, angelica, red paeonia, hemlock parsley, earthworm and peach kernel. The obtained drug has total glucosides of the hoantchy root as 30-60%, total glucosides oftotal glucosides of the red paeonia as 5-20%, content of safflower flavone as 5-10%, and the remains as the other ingredients extracted from the traditional Chinese medicine materials. The yang supplementing five returning ketoside drug provided by the invention can be added with accessories or auxiliary components acceptable in pharmacy to form various preparations required by clinic. The preparations are: small injection solution, transfusion, freeze-dried powder, tablet, capsule, oral solution, buccal tablet, granule, medicinal granules, pill, powder, suspension, suppository, drop, dropping pill, sustained release preparation, release controlling agent and targeting preparation. The drug of the invention has clearly controllable efficacious components, fast absorption, definitive curative effect, convenience for taking and is effective for preventing and treating cardio-cerebral ischemia diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a preparation of Buyang Huanwu total saponins and total flavonoids as the main component, which has significant curative effect on treating cardiovascular and cerebrovascular diseases, and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are frequently-occurring and common diseases of middle-aged and elderly people in modern society, especially cerebral ischemia, which is the most important disease of cerebrovascular diseases, and has the characteristics of high mortality and high disability rate. In the past, most of the prevention and treatment focused on dilating cerebral blood vessels, increasing cerebral blood flow, reducing the area of ​​brain death, and improving neurological function. However, no significant curative effect has been achieved or there are shortcomings such as large side ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K9/02A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P9/10A61K35/64A61K35/62
Inventor 邵旭何万龙童成亮李晓亮牛海军
Owner 合肥七星医药科技有限公司
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