Direct regulation and control effect of peroxisome proliferator-activated receptor alpha on carnitine palmityl transferase 1C, and antitumor application

Abstract

The invention discloses application of a direct regulation and control effect of peroxisome proliferator-activated receptor alpha (PPARalpha) on carnitine palmityl transferase 1C in antitumor. The invention finds the direct regulation and control effect of the PPARalpha on the CPT1C in a human body for the first time, and proves the CPT1C to be as a target gene of the PPARalpha, so that the phenomenon that a PPARalpha-CPT1C regulation and control system can change the growth and proliferation capacity of tumor cells so as to further influence an ageing process of the tumor cells is further proved. The invention provides a new basis for antitumor drug research adopting the PPARalpha and the CPT1C as target spots, and provides a new theoretical basis for screening by adopting a ligand of the PPARalpha as an antitumor drug.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of the direct regulation effect of peroxisome proliferator-activated receptor alpha (PPARα) on carnitine palmitoyltransferase 1C (CPT1C) in anti-tumor. Background technique [0002] Carnitine palmitoyltransferase 1C (CPT1C) is a mitochondrial transferase that catalyzes the initial stage of β-oxidation of fatty acids. It plays an important role in energy metabolism, food intake, and fatty acid oxidation in vivo. New discoveries in recent years suggest that CPT1C, as a novel regulator of tumor cell aging, provides a potential new target for tumor diagnosis and therapy based on mitochondrial dysfunction and cell aging. [0003] Peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor, which is closely related to the expression of fatty acid oxidation-related genes and the process of oxidation in the human body. ...

AI Technical Summary

Problems solved by technology

However, how PPARα plays a role in the anti-tumor process remains to be further studied

[0004] In the current research, the relationship between PPARα and the occurrence and development of human tumors has not been elucidated. It has been reported that inhibiting the expression of PPARα can lead to the arrest of renal cancer cell cycle and promote cell apoptosis; the effect of PPARα agonists on gastric cancer cells Proliferation exhibits a dose-dependent effect

However, whether the expression of PPARα is down-regulated by molecular biological means or its specific inhibitor is used, the growth and proliferation of tumor cells will be inhibited, and the senescence of tumor cells will be induced.

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