Unlock instant, AI-driven research and patent intelligence for your innovation.
Application of a class of 1,2,3-triazole-5-amide compounds as agricultural fungicides
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of amide compounds and agricultural fungicides, applied in class 1, can solve problems such as poor safety, weak work foundation, and late start
Active Publication Date: 2019-02-15
NANJING AGRICULTURAL UNIVERSITY
View PDF6 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Due to the weak foundation and late start of my country's new pesticide creation work, the main varieties in the current market have been controlled by foreign multinational pesticide companies for a long time, resulting in the prevention and control of many major crop pests that have always relied on low activity, large dosage, many residues, and poor safety. pesticide
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0017] Example 1: Preparation of 2-chloro-N-(1-(4-chlorophenyl)-1,2,3-triazole-5)benzamide (compound 1)
[0018]
[0019] Dissolve 2-chlorobenzoic acid in SOCl 2 Reflux at 80°C for 120 minutes, and distill under reduced pressure to remove excess SOCl 2 , Get o-chlorobenzoyl chloride. Under the condition of -78℃ and nitrogen protection, 2mmol of n-butyl lithium was added dropwise to 2mL of dry tetrahydrofuran, and then 2mmol of dry acetonitrile was slowly added dropwise. After stirring for 5 minutes, the substituted 4-chloro dissolved in 2mL of tetrahydrofuran Phenyl azide (2mmol) was slowly added dropwise into the reaction flask, returned to normal temperature and stirred for 120 minutes. After the reaction, purified by silica gel column to obtain 4-chlorophenyl-5-amino-1,2,3-triazole . Take 1 mL of o-chlorobenzoyl chloride, add 1 mmol 4-chlorophenyl-5-amino-1,2,3-triazole, add a small amount of NaH under ice bath, stir at room temperature overnight, and purify by silica gel col...
Embodiment 2
[0020] Example 2: Preparation of 2-chloro-N-(1-(4-fluorophenyl)-1,2,3-triazole-5)benzamide (compound 2)
[0021]
[0022] The preparation method is the same as in Example 1. Replace 4-chlorophenyl azide with 4-fluorophenyl azide to prepare the target compound. The product is a white powder with a yield of 62.3%. m.p.141.3-141.5℃. 1 H NMR(600MHz, DMSO-d 6 )δ10.96(s, 1H), 8.04(s, 1H), 7.69-7.65(m, 2H), 7.56-7.51(m, 4H), 7.44(dd, J=7.6, 1.8Hz, 1H). ESI -MS m / z: 317.07(C 15 H 11 ClFN 4 O, [M+H] + ).
Embodiment 3
[0023] Example 3: Preparation of 2-chloro-N-(1-(3,4-dichlorophenyl)-1,2,3-triazole-5)benzamide (compound 3)
[0024]
[0025] The preparation method is the same as in Example 1. Replace 4-chlorophenyl azide with 3,4-dichlorophenyl azide to prepare the target compound. The product is a white powder with a yield of 60.1%. m.p.155.1-155.5℃. 1 H NMR(600MHz, DMSO-d 6 )δ11.07(s, 1H), 8.07(s, 1H), 8.02(d, J=2.4Hz, 1H), 7.91(d, J=8.6Hz, 1H), 7.67(dd, J=8.6, 2.4 Hz, 1H), 7.60-7.55 (m, 2H), 7.53 (td, J=7.7, 1.5 Hz, 1H), 7.48-7.44 (m, 1H). ESI-MS m / z: 367.04 (C 15 H 10 Cl 3 N 4 O, [M+H] + ).
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention relates to the field of organic chemistry and agricultural pharmacology and discloses a derivative containing a 1,2,3-triazole-5-amide structure and a preparation method and application thereof. The 1,2,3-triazole-5-amide compound is characterized in that the general formula of the compound is as shown in the specification. In the formula, R1 is selected from groups as shown in the specification and R2 is selected from groups as shown in the specification. The compound has a good antibacterial activity to phytopathogen and can be used as an agricultural fungicide for plantdisease control.
Description
Technical field [0001] The invention relates to the synthesis of a class of 1,2,3-triazole-5-amide compounds and their application as fungicides in the prevention and control of plant diseases. Background technique [0002] Pesticides are an indispensable means of production to ensure stable and high yields in agriculture. Their innovative level and leading ability are of irreplaceable significance for food, food and ecological safety. Due to the weak foundation of the creation of new pesticides in my country and the late start, the main varieties in the current market have long been constrained by foreign multinational pesticide companies, resulting in the prevention and control of many major crop pests that have been dependent on low activity, large dosage, large residue, and poor safety. pesticide. Therefore, finding and developing new pharmaceuticals with independent intellectual property rights with high efficiency, low toxicity, strong selectivity and good environmental com...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More