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Application of AhR (Aryl hydrocarbon receptor) protein inhibitor to preparation of antiviral drugs

A technology of antiviral drugs and receptor proteins, applied in the field of biomedicine, can solve the problems of lack of structure-activity relationship research, inability to provide consistent mechanism explanations, and constraints on the research and development process of traditional Chinese medicines, etc.

Inactive Publication Date: 2017-06-20
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the difficulty in the research and development of antiviral traditional Chinese medicine lies in the fact that most of the research focuses on the analysis of their respective drug effects, which cannot provide a consistent mechanism explanation, resulting in a lack of research on the corresponding structure-activity relationship. These problems have seriously restricted the development process of traditional Chinese medicine in China

Method used

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  • Application of AhR (Aryl hydrocarbon receptor) protein inhibitor to preparation of antiviral drugs
  • Application of AhR (Aryl hydrocarbon receptor) protein inhibitor to preparation of antiviral drugs
  • Application of AhR (Aryl hydrocarbon receptor) protein inhibitor to preparation of antiviral drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 Baicalin anti-influenza virus H3N2 virus test

[0059] The H3N2 virus was cultured and replicated in alveolar epithelial cells A549 and macrophage ana-1, and baicalin was added to intervene, and no drug control was set. After routine observation, the results showed that baicalin significantly weakened the ability of influenza virus in alveolar epithelial cells A549 and macrophage ana-1. The replication of phagocytic ana-1 and the reduction of MDCK cytopathy (such as figure 1 shown).

Embodiment 2

[0060] Embodiment 2 Baicalin inhibits HBV test

[0061] Routinely culture hepG2.2.15 cells, add baicalin for intervention, and set no drug control, after routine observation, the results show that baicalin can inhibit hepG2.2.15 secretion of HBsAg, HBeAg and intracellular HBV-RNA levels (such as figure 2 shown).

Embodiment 3

[0062] Example 3 Baicalin down-regulates AhR receptor protein transcription level test

[0063] Add baicalin to wild-type HBV (HepG2. 2.15 cells) and the drug-resistant mutant HBV transfection cell line model can effectively produce combined effects with ETV (such as image 3 shown).

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Abstract

The invention belongs to the technical field of biological medicine, and relates to antiviral drugs, in particular to application of a host AhR (Aryl hydrocarbon receptor) protein inhibitor baicalin compound or a composition of the baicalin compound and other antiviral drugs to preparation of drugs for clinical treatment of various virus infective diseases. The baicalin compound has the functions of interfering with a host AhR protein signal channel, blocking virus replication and further antagonizing the activity of various viruses. The baicalin compound can be made into a pharmaceutical composition with other anti-virus drugs to be used for treating diseases like hepatitis B virus, influenza virus, herpes virus and syncytial virus.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to antiviral drugs, in particular to a host AhR receptor protein inhibitor baicalin compound or a composition with other antiviral drugs used in the preparation of drugs for the clinical treatment of various viral infection diseases the use of. Background technique [0002] According to research reports, factors such as rapid virus mutation and drug resistance and unclear pathogenesis of viral infection have caused the current specific prevention and treatment methods targeting viruses to fall into a dilemma. Taking influenza virus as an example, the rapid mutation of virus strains and the lack of pandemic prediction methods have led to a significant reduction in the effectiveness of preventive influenza vaccines and also led to increasingly widespread drug resistance, which makes influenza prevention and treatment face great challenges. HBV, another major infectious disease virus...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/352A61P31/12A61P31/14A61P31/16A61P31/22A61P31/20
CPCA61K31/7048A61K31/352
Inventor 史训龙朱海燕黄海周伟周珮李继扬
Owner FUDAN UNIV
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