Porous silicon dioxide medicinal accessory for solubilizing itraconazole as well as preparation and applications of porous silicon dioxide medicinal accessory
A technology of porous silica and itraconazole, which is applied in the direction of drug delivery, drug combination, and medical preparations of non-active ingredients, etc., can solve problems such as the treatment of dysentery mycosis, and achieve the promotion of dissolution onset and reduction of drug side effects , reduce the effect of intestinal irritation
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Embodiment 1
[0035] Such as figure 1 As shown, add 30mL of toluene, 0.11g of aminopropyltriethoxysilane, and 6g of commercial drug flow agent silicon oxide in the three-necked flask successively, and the specific surface area of the silicon oxide is 410m 2 / g, pore size 3-15nm, reflux at 80°C for 24h. Then the obtained product was subjected to suction filtration, washed three times with 20 mL of ethanol respectively, and the product obtained by suction filtration was dried in an oven at 60° C. for 12 hours to obtain the aminopropyl-modified silicon oxide drug excipient of this example.
[0036] Dissolve 1 g of itraconazole into a beaker of 30 mL of dichloromethane, add 1 g of aminopropyl-modified silicon oxide, and stir at room temperature for 0.5 hours. The mixed solution was transferred to a rotary evaporator, set the temperature at 30°C, and distilled under reduced pressure until the dichloromethane volatilized completely. Then put the product in an oven at 60° C. and dry it for 10 ...
Embodiment 2
[0040] Such as figure 1 As shown, add 30mL of methanol, 0.28g of methyltrimethoxysilane, and 6g of mesoporous silica to the three-necked flask in sequence. The mesoporous silica is SBA-15 with a specific surface area of 740m 2 / g, pore size 6-8nm, reflux at 70°C for 24h. Then the obtained product was subjected to suction filtration, washed three times with 20 mL of ethanol, and the product obtained by suction filtration was dried in an oven at 60° C. for 12 hours. After the drying was completed, the methyl-modified SBA-15 silicon oxide pharmaceutical excipient of this example was obtained.
[0041] Dissolve 1 g of itraconazole into a beaker of 30 mL of dichloromethane, then add 2 g of aminopropyl-modified silicon oxide, and stir at room temperature for 0.5 hours. The mixed solution was transferred to a rotary evaporator, set the temperature at 30°C, and distilled under reduced pressure until the dichloromethane volatilized completely. Then place the product in an oven at 6...
Embodiment 3
[0045] Add 40mL of toluene, 0.16g of hexamethyldisilazane, and 6g of mesoporous silica to the three-necked flask in sequence. The mesoporous silica is MCM-41 with a specific surface area of 820m 2 / g, pore size 3-4nm, reflux at 80°C for 24h. Then the obtained product was subjected to suction filtration, washed three times with 20 mL of ethanol, and the product obtained by suction filtration was dried in an oven at 60° C. for 12 hours. After the drying was completed, the methyl-modified MCM-41 silicon oxide drug excipient of this example was obtained.
[0046] Dissolve 1 g of itraconazole into a beaker of 30 mL of dichloromethane, then add 0.5 g of methyl-modified MCM-41 silicon oxide, and stir at room temperature for 0.5 hours. The mixed solution was transferred to a rotary evaporator, set the temperature at 30°C, and distilled under reduced pressure until the dichloromethane volatilized completely. Then place the product in an oven at 60° C. and dry it for 10 minutes to ob...
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