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3,5,7-trihydroxy-2-(4-hydroxyphenyl)-benzo pyranyl-4-one derivatives

A technology of hydroxyphenyl and benzopyran is applied in the field of 3,5,7-trihydroxy-2--benzopyran-4-one derivatives, which can solve problems such as seed residue and achieve good anti-oxidation The effect of action, stable structure and simple preparation process

Inactive Publication Date: 2017-06-23
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a non-medicinal part, there are still a large number of seeds remaining in addition to the annual seed selection.

Method used

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  • 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-benzo pyranyl-4-one derivatives
  • 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-benzo pyranyl-4-one derivatives
  • 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-benzo pyranyl-4-one derivatives

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Embodiment

[0019] 1) Preliminary extraction:

[0020] Grind 15kg of dry seeds of Desmodium sativa, degrease with petroleum ether, then reflux and extract with 95% ethanol for 3 times, the time of each reflux is 3h, combine the extracts, concentrate under reduced pressure to obtain an extract, add appropriate amount of distilled water to suspend, Then extract with chloroform and water-saturated n-butanol for several times in sequence, and concentrate each part of the extract under reduced pressure to obtain 171 g of chloroform extract, 664 g of n-butanol extract and 893 g of the residue in the water layer.

[0021] 2) Determination of total flavonoid content:

[0022] ① Preparation of test sample solution

[0023] Weigh 63.5mg of chloroform extract, 45.2mg of n-butanol extract, and 175mg of the residue in the water layer, respectively, and place them in three 25mL volumetric flasks, dissolve and dilute to the mark with 70% ethanol, shake well, and refrigerate at 4°C ,stand-by.

[0024]...

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Abstract

The invention discloses 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-benzo pyranyl-4-one derivatives. The preparation method comprises the following steps: 1) pulverizing snowbell-leaf tickclover dry seeds, degreasing with petroleum ether, extracting with ethanol under reflux, carrying out vacuum concentration on the extracting solution to obtain an extract, adding distilled water, suspending, extracting sequentially with chloroform and water-saturated n-butanol, and carrying out vacuum concentration on the extracting solutions to obtain a chloroform extract, an n-butanol extract and water layer residues; and 2) carrying out ODS column chromatography separation, silica gel column chromatography, CHCl3-MeOH elution, polyamide column chromatography and hydroxypropyl dextrangel purification on the n-butanol extract to separate out 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-benzo pyranyl-4-one derivatives in different structures. The 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-benzo pyranyl-4-one derivatives have stable structure, are separated from the snowbell-leaf tickclover seeds, have the advantages of oxidation resistance and simple preparation process, and can be used as a natural antioxidant.

Description

technical field [0001] The invention relates to a 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-benzopyran-4-one derivative. Background technique [0002] Desmodium sativa is the dry aboveground part of the leguminous plant Desmodium sativa. It is a large-scale cultivated medicinal material in Guangdong and Guangxi. It is a species included in the "Chinese Pharmacopoeia". , liver, and gallstones, the clinical effect is remarkable. The Desmodium spp. used in the early days was a wild product. With the increasing demand for medicinal materials, the source of medicinal materials is becoming increasingly scarce. At present, cultivated products have become the main source of commercial medicinal materials. Desmodium spp. is propagated by seeds, and the yield of medicinal seeds is considerable. However, as a non-medicinal part, there are still a large number of seeds remaining except for the annual selection and retention of seeds. The research on the seeds of Desmodium spp. mainly focu...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/00A61P39/06
CPCC07H17/07C07H1/00
Inventor 程轩轩杨全
Owner GUANGDONG PHARMA UNIV
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