Compound preparation for treating rheumatoid arthritis and preparation method of compound preparation

A compound preparation, rheumatoid technology, applied in the field of preparation of the aforementioned compound preparation

Inactive Publication Date: 2017-06-30
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its efficacy in the treatment o...

Method used

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  • Compound preparation for treating rheumatoid arthritis and preparation method of compound preparation
  • Compound preparation for treating rheumatoid arthritis and preparation method of compound preparation
  • Compound preparation for treating rheumatoid arthritis and preparation method of compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 600g of fried burdock, 500g of silkworm, 900g of notoginseng, 500g of duhuo, 400g of Gentiana chinensis, and 500g of pinellia.

[0034] Take each raw material, soak for 1 hour, decoct for 2 times, decoct for 1 hour each time, add 14 times of water for the first decoction, add 10 times of water for the second decoction, combine the decoction liquid, filter, and concentrate the filtrate to a relative density of 1.05- 1.07 extract, for subsequent use;

[0035] Add ethanol to the above extract to make the alcohol concentration 50-80%, let it stand overnight, and concentrate the supernatant until the density is 1.3-1.4;

[0036] The concentrated extract was dried under reduced pressure and crushed to obtain extract powder. The extract powder is added with medicinal excipients, mixed evenly, granulated, pressed into 1000 tablets, 0.45g per tablet, and taken 10 tablets per day. Or make dosage forms such as granules, capsules, mixtures or powders according to the usual ...

Embodiment 2

[0038] Weigh 1000g of fried burdock, 800g of silkworm, 1000g of Panax notoginseng, 800g of duhuo, 600g of Gentiana chinensis, and 1000g of pinellia.

[0039] Take each raw material, soak for 1 hour, decoct twice, each time for 1 hour, add 8-10 times of 50-90% ethanol for the first decoction, add 6-10 times of 50-90% ethanol for the second decoction, and decoct together liquid, filtered, and the filtrate was concentrated to an extract with a relative density of 1.3-1.4, and set aside.

[0040] The concentrated extract was dried under reduced pressure and crushed to obtain extract powder.

[0041] The extract powder is added with medicinal excipients, mixed evenly, granulated, pressed into 1000 tablets, 0.45g per tablet, and taken 10 tablets per day. Or make dosage forms such as granules, capsules, mixtures or powders according to the usual methods in pharmacy.

Embodiment 3

[0043]Weigh 650g of fried burdock, 550g of silkworm, 9500g of notoginseng, 550g of duhuo, 450g of Gentiana chinensis, and 550g of pinellia.

[0044] Take each raw material, soak for 1 hour, decoct for 2 times, decoct for 1 hour each time, add 8-10 times of 50-90% ethanol for the first decoction, add 6-10 times of water for the second decoction, filter the decoction, and concentrate to the relative The extract with a density of 1.3-1.4 is set aside.

[0045] The concentrated extract was dried under reduced pressure and crushed to obtain extract powder.

[0046] Add medicinal excipients to the extract powder, mix well, granulate, press into 1000 tablets, 0.45g per tablet, take 10 tablets per day. Or make dosage forms such as granules, capsules, mixtures or powders according to the usual methods in pharmacy.

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Abstract

The invention relates to a compound preparation for treating rheumatoid arthritis. The compound preparation is prepared from the following crude drugs in parts by weight: 5 to 12 parts of fried fructus arctii, 4 to 11 parts of bombyx batryticatus, 8 to 15 parts of radix notoginseng, 4 to 12 parts of radix angelicae pubescentis, 3 to 9 parts of radix gentianae macrophyllae, and 4 to 12 parts of rhizoma pinelliae. The animal experiment shows that the compound preparation can reduce an inflammatory infiltration area, bony defects and articular cartilage defects of TNF-Tg rheumatoid arthritis mice, can promote lymphatic return and can alleviate ankle joint inflammatory injury. The traditional Chinese medicine compound preparation can improve the rheumatoid arthritis symptom, and can avoid the inconvenience caused by the temporary decoction of the traditional Chinese herbal decoction before the administration and the likeliness in mildew; and in addition, the invention also provides a preparation method of the compound preparation.

Description

technical field [0001] The invention relates to a compound preparation for treating rheumatoid arthritis; in addition, the invention also relates to a preparation method of the aforementioned compound preparation. Background technique [0002] The prior art discloses that rheumatoid arthritis (Rheumatoid Arthritis, RA) is a chronic, systemic, progressive, autoimmune disease characterized by widespread persistent synovitis and symmetrical, destructive joint Lesions are characteristic. The treatment of RA is very difficult, so far, there is still a lack of safe and effective drugs. Modern medicine is mainly about anti-inflammation and alleviating sequelae. Drugs such as TNFα inhibitors Etanercept, Infliximab and Adalimumab can reduce some objective symptom indicators such as swelling and tender joint counts to 50% in some RA patients, but many patients still have problems in initial treatment. Its non-response, or the failure of the second treatment, an average of about 10% ...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P19/02A61P29/00A61K35/64
Inventor 梁倩倩施杞王拥军李金龙刘书芬陈岩李强张利徐浩王腾腾赵永见王琼齐晓凤
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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