Microfluidic chip sample injection system and adaptive pipe

Abstract

The invention relates to the technical field of microfluidic chips and discloses a microfluidic chip sample injection system and an adaptive pipe. The microfluidic chip sample injection system comprises microfluidic chips, a negative pressure generating device, and a container for holding samples; the microfluidic chips are provided with fluid passages, and each of the fluid passages is provided with a passage inlet and a passage outlet; the negative pressure generating device is connected with the passage outlet through an adaptive pipe; the adaptive pipe is provided with a check valve structure for preventing gas from flowing back through the passage outlet into the fluid passage. The adaptive pipe is applied to the microfluidic chip sample injection system, wherein the check valve structure comprises a light valve core arranged in a tube body. The microfluidic chip sample injection system provides the homogeneity of sample injecting, and can effectively save the consumption of precious samples. The adaptive pipe enables the sample injection effect of the sample to be more excellent.

Description

technical field [0001] The invention relates to the technical field of microfluidic chips, in particular to a microfluidic chip sampling system and an adapter tube. Background technique [0002] Microfluidic chip technology is one of the rapidly developing frontier fields of high-tech and interdisciplinary science and technology. It is an important technical platform for the research of signal detection and processing methods in life sciences, chemical sciences and information sciences. [0003] In the design of microfluidic chip system, fluid drive and control are the key, which can be divided into pressure drive, electric drive, thermal drive, and surface tension drive, among which pressure drive is the mainstream technology of fluid drive. [0004] At present, the pressure drive mainly uses positive pressure to press the fluid into the chip. The process is simply to squeeze the sample into the microfluidic channel of the chip by increasing the pressure on the fluid sample...

AI Technical Summary

Problems solved by technology

[0004] At present, the pressure drive mainly uses positive pressure to press the fluid into the chip. The process is simply to squeeze the sample into the microfluidic channel of the chip by increasing the pressure on the fluid sample. However, with the reduction of the size of the microfluidic chip With the increasing complexity of microchannels, the positive pressure method exposes the following disadvantages: First, the flow resistance encountered during fluid injection is large, which increases the difficulty of sample injection.

Second, after the fluid sample is injected, there is a high possibility of residual gas in the fluid channel, and it is difficult for the sample to be pressed into the volume occupied by the residual gas, so it is difficult to achieve the uniformity of the sample filling, and even cause the sample injection to fail; third, positive The pressure method generally requires a certain amount of sample to achieve smooth sample injection, which causes a lot of waste for some precious samples

To solve this problem, in the prior art, micro valves and micro pumps are used to control the flow, but this type of system is costly and has strict requirements on fluid pressure and flow.

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