Pharmaceutical composition for treating qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae of ischemic stroke and preparation method, preparation and application thereof

A technology for ischemic stroke, qi deficiency and blood stasis, applied in the field of medicine, can solve the problems of complex composition, dysfunction, long-term neurological function, etc.

Inactive Publication Date: 2017-07-04
昆明市中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rehabilitation of nerve damage after stroke is difficult. Currently, there is no specific drug for the recovery of nerve damage. The recovery of nerve function in clinical practice often takes a long time, and most of them have different degrees of dysfunction
There are also many Chinese patent medicines for the treatment of apoplexy in clinical practice, but their composition is often complicated, and the long-term efficacy and mechanism of action need to be further verified
At present, there is no more effective drug for the treatment of the above-mentioned diseases on the market, therefore, it is very necessary to develop a drug for the treatment of the above-mentioned diseases

Method used

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  • Pharmaceutical composition for treating qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae of ischemic stroke and preparation method, preparation and application thereof
  • Pharmaceutical composition for treating qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae of ischemic stroke and preparation method, preparation and application thereof

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preparation example Construction

[0018] The preparation method of the pharmaceutical composition for treating qi deficiency and blood stasis type ischemic stroke convalescence and its sequelae according to the present invention includes the steps of extraction, concentration and drying, specifically comprising:

[0019] A. Extraction: Mix the raw materials in the formula ratio, add water with a total weight of 3~8 raw materials, extract 2~4 times at a temperature of 40~80°C, each time for 2~8h, filter, and combine the filtrates to obtain the extract a;

[0020] B. Concentration: Concentrate the extract a under reduced pressure to a relative density of 1.01-1.03 to obtain the extract b;

[0021] C. Drying: dry the extract b at low temperature until the water content is 5-8%, pulverize and sieve to obtain the target pharmaceutical composition for treating ischemic apoplexy of Qi-deficiency and blood-stasis type in the recovery period, ie sequelae.

[0022] 6. The preparation method according to claim 5, charact...

Embodiment 1

[0029] Weigh 180g of Radix Astragali, 120g of Panax notoginseng, and 80g of Earthworm, crush them through a 10-mesh sieve, add water with a weight of 3, extract twice at a temperature of 80°C, each time for 2h, filter, combine the filtrates to obtain an extract, and reduce the extract to Concentrate under pressure to a relative density of 1.01 to obtain an extract; dry the extract at low temperature to a water content of 8%, and crush it through a 100-mesh sieve to obtain a pharmaceutical composition for treating the sequelae of ischemic stroke of the Qi-deficiency and blood-stasis type.

Embodiment 2

[0031] Weigh 200g of astragalus, 150g of notoginseng, and 100g of earthworm, crush them through a 10-mesh sieve, add water with a weight of 8, extract 4 times at a temperature of 40°C, filter every 8h, combine the filtrates to obtain an extract, and decompress the extract Concentrating to a relative density of 1.03 to obtain an extract; drying the extract at low temperature to a water content of 8%, pulverizing and passing through a 200-mesh sieve to obtain a pharmaceutical composition for treating the sequelae of ischemic stroke of the Qi-deficiency and blood-stasis type.

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Abstract

The invention discloses pharmaceutical composition for treating a qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae of ischemic stroke and a preparation method, preparation and application thereof. The pharmaceutical composition for treating the qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae of ischemic stroke is prepared from the raw materials in parts by weight: 180 to 720 parts of radix astragali seu hedysari, 120 to 480 parts of radix notoginseng and 80 to 320 parts of pberetima and through the steps of extracting, concentrating an drying. The preparation is tablet, powder, capsule, granula or pill which is prepared through adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition for treating the qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae of ischemic stroke. The application is application of the pharmaceutical composition for treating the qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae of ischemic stroke in preparing medicine for treating hemiplegia, skin numbness and alalia caused by the qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae stage. The whole formula of the pharmaceutical composition disclosed by the invention has effects of tonifying qi, dredging collaterals and activating blood. The pharmaceutical composition is suitable for the qi deficiency and blood stasis type ischemic stroke restoration stage and sequelae stage.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating ischemic stroke convalescence and sequelae of qi deficiency and blood stasis type, a preparation method, preparation and application thereof. Background technique [0002] Ischemic stroke is one of the most important chronic diseases in my country. Nerve damage after ischemic stroke often leads to hemiplegia or hemiplegia, skin numbness, and slurred speech. Rehabilitation of nerve damage after stroke is difficult. Currently, there is no specific drug for nerve damage recovery. In clinical practice, the recovery of nerve function often takes a long time, and most of them have different degrees of dysfunction. There are also many Chinese patent medicines for the treatment of apoplexy in clinical practice, but their composition is often complicated, and the long-term efficacy and mechanism of action need to be further verified. ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P9/10A61K35/62
CPCA61K35/62A61K36/258A61K36/481A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 顾力华石丽琼陈奇刚谢青刘朵
Owner 昆明市中医医院
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