Application of CTCF snare protein in preparation of anti-uveal melanoma medicine

A technology for melanoma and uvea, which is applied in the field of application of CTCF trap protein in the preparation of anti-uveal melanoma drugs, can solve the problems of unclear curative effect and mechanism of action of uveal melanoma, reduce the enucleation rate, improve Effectiveness of treatment, effect of improving visual prognosis
CN106913861AActive Publication Date: 2017-07-04SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Publication Date
2017-07-04

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Abstract

The invention relates to the field of anticancer medicines and particularly discloses an application of a CTCF snare protein in preparation of an anti-uveal melanoma medicine. The CTCF snare protein is an artificially expressed recombinant protein, wherein N-terminal and C-terminal functional zones of a wild-type CTCF are removed, while a zinc finger structure ZF is remained and DNA methylase Sss1 is added. A researching result proves that by transferring the CTCF snare in an UM cell, growth and metastasis of the uveal melanoma can be effectively inhibited. The CTCF snare protein provides a new target point and a therapy medicine for clinical treatment of the uveal melanoma, improves therapy validity, reduces rate of eyeball removal, and improves visional prognosis of patients.
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Description

technical field

[0001] The invention belongs to the field of antitumor drugs, and in particular relates to the application of a CTCF trap protein in the preparation of anti-uveal melanoma drugs. Background technique

[0002] Uveal melanoma (Uveal melanoma, UM) is the most common primary intraocular malignant tumor in adults. UM usually occurs unilaterally and unifocally, but rare cases of bilateral or multifocal tumors within the same eye occur. UM has a high degree of malignancy, which can not only lead to vision loss, but also easily metastasize to the blood, mainly to the liver, which seriously threatens the life of the patient. Due to the lack of effective early diagnosis and treatment methods, UM patients often die within one year after diagnosis. Even if the affected eye is enucleated without definite distant metastasis, the 5-year mortality rate is still as high as 17%-53%. In recent years, the incidence of melanoma has shown an increasing trend, with an annual gro...

Claims

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