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An NGF-containing pharmaceutical composition used for treating corneal epithelium injuries

A technology of corneal epithelium and composition, which is applied in the field of medicine to achieve the effect of reducing adverse reactions, promoting damage repair, and promoting proliferation

Active Publication Date: 2017-07-14
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no report has been found containing NGF alone or in combination with other active ingredients for repairing corneal epithelial damage

Method used

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  • An NGF-containing pharmaceutical composition used for treating corneal epithelium injuries
  • An NGF-containing pharmaceutical composition used for treating corneal epithelium injuries
  • An NGF-containing pharmaceutical composition used for treating corneal epithelium injuries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 eye drops

[0041] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0042]

Embodiment 2

[0043] Embodiment 2 eye drops

[0044]Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0045]

Embodiment 3

[0046] Embodiment 3 eye drops

[0047] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0048]

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PUM

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Abstract

An NGF-containing pharmaceutical composition used for treating corneal epithelium injuries is disclosed. The composition includes an NGF (preferably a human-derived NGF). The composition (in a form of eye drops preferably) can promote proliferation and clonality capabilities of corneal limbal stem cells, and can effectively promote corneal epithelium injury healing including healing of continuous corneal epithelium injuries, diabetic keratopathy treatment, nervous keratitis treatment and treatment of corneal limbal stem cell deficiency.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition containing NGF for treating corneal epithelial damage. Background technique [0002] The transparency and functional integrity of the cornea depend on the normal structure and metabolism of each layer of the cornea, and the outermost corneal epithelial tissue undoubtedly plays a very important role in this. Various physical damage, chemical damage, mechanical damage, pathogenic microorganisms, endocrine and immune factors can cause corneal epithelial damage. The corneal epithelium is a physical barrier against the invasion of external pathogenic factors. The maintenance of its integrity depends on the tight junction and anchor junction between epithelial cells, cells and basement membrane, and the continuous self-renewal of epithelial cells. Damage to the corneal epithelium can affect the connection between cells, causing changes in the permeability...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K38/17A61P27/02
CPCA61K38/1793A61K38/185A61K9/0048A61K2300/00
Inventor 齐虹高彩凤
Owner PEKING UNIV THIRD HOSPITAL
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