An NGF-containing pharmaceutical composition used for treating corneal epithelium injuries
A technology of corneal epithelium and composition, which is applied in the field of medicine to achieve the effect of reducing adverse reactions, promoting damage repair, and promoting proliferation
Active Publication Date: 2017-07-14
PEKING UNIV THIRD HOSPITAL
View PDF2 Cites 5 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, no report has been found containing NGF alone or in combination with other active ingredients for repairing corneal epithelial damage
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0040] Embodiment 1 eye drops
[0041] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:
[0042]
Embodiment 2
[0043] Embodiment 2 eye drops
[0044]Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:
[0045]
Embodiment 3
[0046] Embodiment 3 eye drops
[0047] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:
[0048]
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
An NGF-containing pharmaceutical composition used for treating corneal epithelium injuries is disclosed. The composition includes an NGF (preferably a human-derived NGF). The composition (in a form of eye drops preferably) can promote proliferation and clonality capabilities of corneal limbal stem cells, and can effectively promote corneal epithelium injury healing including healing of continuous corneal epithelium injuries, diabetic keratopathy treatment, nervous keratitis treatment and treatment of corneal limbal stem cell deficiency.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition containing NGF for treating corneal epithelial damage. Background technique [0002] The transparency and functional integrity of the cornea depend on the normal structure and metabolism of each layer of the cornea, and the outermost corneal epithelial tissue undoubtedly plays a very important role in this. Various physical damage, chemical damage, mechanical damage, pathogenic microorganisms, endocrine and immune factors can cause corneal epithelial damage. The corneal epithelium is a physical barrier against the invasion of external pathogenic factors. The maintenance of its integrity depends on the tight junction and anchor junction between epithelial cells, cells and basement membrane, and the continuous self-renewal of epithelial cells. Damage to the corneal epithelium can affect the connection between cells, causing changes in the permeability...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): A61K38/18A61K38/17A61P27/02
CPCA61K38/1793A61K38/185A61K9/0048A61K2300/00
Inventor 齐虹高彩凤
Owner PEKING UNIV THIRD HOSPITAL
PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.
