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Synchronous multi-analyte sensing test paper for isolating current interference by sample feeding gaps and application of synchronous multi-analyte sensing test paper

An analyte and injection port technology, applied in the field of simultaneous multi-analyte sensing test paper, can solve the problems of impossibility of accuracy and effectiveness

Pending Publication Date: 2017-08-01
GUILIN ROYALYZE MEDICAL INSTR +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the actual sample injection process, the blood sample touches the blood inlet and enters the double chamber under the action of siphon. When the dual-chamber electrode is connected to the residual blood sample, the independent dual-chamber design no longer exists, and the current signals generated by the dual-chamber electrodes must mix, superimpose, interfere or cancel each other. The current signal read by the analyzer is Synthetic results of two analytes, not likely to be accurate and valid

Method used

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  • Synchronous multi-analyte sensing test paper for isolating current interference by sample feeding gaps and application of synchronous multi-analyte sensing test paper
  • Synchronous multi-analyte sensing test paper for isolating current interference by sample feeding gaps and application of synchronous multi-analyte sensing test paper
  • Synchronous multi-analyte sensing test paper for isolating current interference by sample feeding gaps and application of synchronous multi-analyte sensing test paper

Examples

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preparation example Construction

[0066] The preparation method of the above-mentioned synchronous multi-analyte sensing test paper that isolates the current interference from the sampling gap comprises the following steps:

[0067] 1) Process a first sampling notch 1-1 on the first insulating substrate 1; process a second sampling notch 7-1, a first via hole 7-2, a second sampling notch 7 on the second insulating substrate 7 Two via holes 7-3 and a substrate gap 7-4;

[0068] 2) Print the first conductive film layer 2 on the first insulating substrate 1, put it in an oven at 70-90°C and dry it for 50-70min to form the first reactant working electrode 2-1 and the second reactant working electrode 2 -2;

[0069] 3) Spray the first reaction film 3-1 on the first reactant working electrode 2-1, then spray the second reaction film 3-2 on the second reactant working electrode 2-2, and then 40-60°C Dry for 10-30min and set aside;

[0070] 4) Paste the liquid guide tank body 4 with the third sampling notch 4-1 on ...

Embodiment 1

[0080] This example provides a preparation example of a multi-analyte sensing test paper for detecting glucose and total cholesterol in blood, thereby illustrating the method for preparing a synchronous multi-analyte sensing test paper that isolates current interference through the sampling gap of the present invention. The preparation method Including the following steps:

[0081] 1) Process a first sampling notch 1-1 on the first insulating substrate 1; process a second sampling notch 7-1, a first via hole 7-2, a second sampling notch 7 on the second insulating substrate 7 Two via holes 7-3 and a substrate gap 7-4;

[0082] 2) Print the first conductive film layer 2 on the first insulating substrate 1, put it in an oven at 80° C. and dry it for 60 minutes to form the first reactant working electrode 2-1 and the second reactant working electrode 2-2;

[0083] 3) Spray the first reaction membrane 3-1 enzyme solution that reacts with glucose in the blood, that is, the blood gl...

Embodiment 2

[0100] In this embodiment, the simultaneous multi-analyte sensing test paper prepared in Example 1 and the simultaneous multi-analyte sensing test paper prepared in Example 1 with a sample injection gap to isolate current interference and the simultaneous multi-analyte sensing test paper in Comparative Example 1 were used to test blood samples.

[0101]Collect fresh venous blood, adjust the hematocrit ratio to 40%, prepare two blood samples, test the blood sugar concentration with a YSI2300 glucose analyzer, and test the total cholesterol with a biochemical analyzer and a Fosun Long March total cholesterol biochemical kit. Test the synchronous multi-analyte sensing test paper with the sample injection gap to isolate current interference prepared in Example 1, place it in a supporting multi-parameter analyzer and apply a 300mV working voltage at both ends of the working electrode and the reference electrode; take the prepared blood sample, When it is added to the sampling gap, t...

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Abstract

The invention discloses synchronous multi-analyte sensing test paper for isolating current interference by sample feeding gaps and application of the synchronous multi-analyte sensing test paper. The test paper comprises a first insulating substrate and a second insulating substrate, and two mutually independent detection systems which are arranged on the first insulating substrate and the second insulating substrate respectively, wherein the first insulating substrate is provided with a first sample feeding gap; the second insulating substrate is provided with a second sample feeding gap; a third sample feeding gap is formed in a liquid guide groove body; shapes and sizes of the first sample feeding gap, the second sample feeding gap and the third sample feeding gap are the same; after the first insulating substrate, the liquid guide groove body and the second insulating substrate are stacked in sequence, a stacked sample feeding gap is formed; a first sample feeding opening and a second sample feeding opening are formed in end faces at two sides of a feeding depth direction of the stacked sample feeding gap respectively. According to the test paper disclosed by the invention, current mutual interference between different analyte reaction systems is isolated through the stacked sample feeding gap, and two or more items can be accurately detected after one piece of test paper is fed into a sample for one time.

Description

technical field [0001] The invention belongs to the technical field of precise biosensing detection, and relates to a synchronous multi-analyte sensing test paper with a sampling gap that isolates current interference and an application thereof. Background technique [0002] In medical institutions and patients' families, test strips and analyzers produced based on biosensing electrochemical technology can quickly detect the concentration of human blood sugar, ketone bodies, urine sugar, uric acid, cholesterol, triglycerides, hemoglobin and other chemical markers. It only needs to collect a small amount of blood or a small amount of urine sample, inhale the biosensing electrochemical test paper and connect it to the analyzer, and the test result can be obtained in a short time. For example, the publication number CN1447113A discloses "blood glucose tester supporting test paper and its manufacturing method" introduction, the test paper mainly includes: a substrate, a working ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/27
CPCG01N27/27
Inventor 梁明龙李中伍寿胜崔晓斌刘勤廖姗
Owner GUILIN ROYALYZE MEDICAL INSTR
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