Device and method for hemorrhage detection and guided resuscitation and applications of same

A technology for monitoring devices and blood vessels, applied in applications, special data processing applications, catheters, etc., can solve problems such as harsh environments, ineffective monitoring devices, and lack of remote monitoring

Active Publication Date: 2017-08-01
VANDERBILT UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Casualty care or rural settings present several unique challenges, namely, harsh environments, lim

Method used

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  • Device and method for hemorrhage detection and guided resuscitation and applications of same
  • Device and method for hemorrhage detection and guided resuscitation and applications of same
  • Device and method for hemorrhage detection and guided resuscitation and applications of same

Examples

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example 1

[0108] In one example, offers include but are not limited to Figure 3B The wristband-based device shown is a wearable device in place of a desktop system. This example focuses on optimizing piezoelectric transducers and evaluating transducer systems based on miniature piezoelectric film / foil (LDT0-028K-Measurement Specialties, Hampton, VA). Specifically, LDT0-028K is a flexible part consisting of a 28 μm thick piezoelectric PVDF polymer film with a polyester substrate laminated to 0.125 mm and equipped with two crimped contact points of screen-printed Ag-ink electrodes. When the piezoelectric film is subjected to motion, it is displaced from the mechanical neutral axis, and the bending produces very high strains and thus high voltages within the piezoelectric polymer. The resulting voltage can be directly interfaced to the analog-to-digital converter of a desktop data acquisition system or a stand-alone microcontroller system using a resistor network. In one embodiment, an...

example 2

[0124] In certain embodiments, a device is validated using non-invasive vascular waveform analysis for detection and staging of bleeding in humans. According to the Institutional Review Board, the inventors planned to enroll 50 patients undergoing coronary artery bypass surgery with normal ventricular and valve function. It is standard practice for patients to undergo preoperative autologous blood donation in order to preserve coagulation factors that are often depleted during cardiopulmonary bypass. Cardiac surgery also provides the opportunity to compare real-time changes in hemodynamic parameters with those of our device in a challenging heterogeneous group of patients.

[0125] Before starting surgery, patients were induced with general anesthesia and mechanically ventilated. Invasive monitors were inserted according to standard anesthesia protocol including central venous, pulmonary artery, and intra-arterial catheterization. Transesophageal echocardiography was routine...

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Abstract

Aspects of the invention relates to systems and methods for detecting volume status, volume overload, dehydration, hemorrhage and real time assessment of resuscitation, as well as organ failure including but not limited cardiac, renal, and hepatic dysfunction, of a living subject using non-invasive vascular analysis (NIVA). In one embodiment, a non-invasive device, which includes at least one sensor, is used to acquire vascular signals from the living subject in real time. The vascular signals are sent to a controller, which processes the vascular signals to determine at least one hemodynamic parameter, such as the volume status of the living subject. In certain embodiments, the vascular signals are processed by a spectral fast Fourier transform (FFT) analysis to obtain the peripheral vascular signal frequency spectrum, and the volume status of the living subject may be determined by comparing amplitudes of the peaks of the peripheral vascular signal frequency spectrum.

Description

[0001] Cross references to related patent applications [0002] This PCT application is required under 35 U.S.C. § 119(e) of Susan S. Eagle, Colleen Brophy, Kyle Mitchell Hocking, Franz Baudenbacher, and Richard Boyer, filed November 13, 2014, entitled "Instrumentation for the Detection of Bleeding and Guidance of Resuscitation" DEVICE AND METHOD FOR HEMORRHAGE DETECTION AND GUIDED RESUSCITATION AND APPLICATIONS OF SAME," US Provisional Patent Application Serial No. 62 / 079,367, the entire contents of which are incorporated herein by reference. [0003] This PCT application was also filed on September 14, 2015 by Susan S. Eagle, Colleen Brophy, Kyle Mitchell Hocking, Franz Baudenbacher, and Richard Boyer entitled "Hypovolemia / Hypervolaemia Using Peripheral Venous Waveform Analysis (PIVA) HYPOVOLEMIA / HYPERVOLEMIADETECTIONUSING PERIPHERAL INTRAVENOUS WAVEFORM ANALYSIS (PIVA) AND APPLICATIONS OFSAME," a continuation-in-part of U.S. Patent Application Serial No. 14 / 853,504, itself cl...

Claims

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Application Information

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IPC IPC(8): A61B5/02A61B5/00G06F19/00A61B5/024A61B5/08
CPCA61B5/02007A61B5/02028A61B5/02042A61B5/681A61B5/7257A61B5/0816A61B5/0002A61B5/02438A61B5/7221A61B5/4875G16H40/63
Inventor S·伊格尔C·布罗菲K·霍金F·巴乌德巴谢尔R·波伊尔
Owner VANDERBILT UNIV
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