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Prussian blue-loaded targeting nanocomposite and preparation method thereof

A nanocomposite, Prussian blue technology, applied in the field of Prussian blue-loaded targeted nanocomposite and its preparation, can solve the problem of inability to combine photothermal therapy and chemotherapy comprehensive therapeutic effect, and achieve good photothermal conversion characteristics and photothermal properties. Thermal stability, good photothermal conversion ability, and the effect of improving therapeutic efficacy

Active Publication Date: 2017-08-04
CHONGQING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a gap between PB NPs and ideal diagnostic and therapeutic nanoparticles, because the Prussian blue-based nanoparticles studied so far are all naked, without encapsulation or surface modification, and are easily cleared by the body over time.
Moreover, most of these Prussian blue-based nanocomposites cannot achieve comprehensive therapeutic effects combining photothermal therapy and chemotherapy because they do not carry drugs.

Method used

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  • Prussian blue-loaded targeting nanocomposite and preparation method thereof
  • Prussian blue-loaded targeting nanocomposite and preparation method thereof
  • Prussian blue-loaded targeting nanocomposite and preparation method thereof

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Embodiment Construction

[0052] The preparation method of the present invention carrying the Prussian blue targeting nanocomposite, the specific steps are as follows:

[0053] 1. Preparation of targeted nanocomposites loaded with Prussian blue

[0054] 1. Preparation of Prussian blue nanoparticles

[0055] a. Add 0.5mmol citric acid (98mg) to 20mL FeCl 3 (1.0mmol / L) aqueous solution, stirred at 60°C to obtain solution a;

[0056] b. Then, 20 mL of potassium ferrocyanide K containing an equivalent amount of 0.5 mmol citric acid 4 [Fe(CN) 6 ] (1.0mM) aqueous solution was added dropwise to the above solution a solution, a clear blue solution appeared, and stirred at 60°C for 1 minute;

[0057] c, the solution is cooled to room temperature, and then stirred at room temperature for 30 minutes to obtain a dispersion;

[0058] d. Add the same volume of 40mL acetone to the dispersion, and centrifuge at 28000rpm for 1 hour to form a precipitate of Prussian blue nanoparticles;

[0059] e. Prussian blue na...

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Abstract

The invention discloses a Prussian blue-loaded targeting nanocomposite. The Prussian blue-loaded targeting nanocomposite comprises a PEGylated folic acid targeting lactic acid / glycolic acid copolymer shell coating Prussian blue nanoparticles, wherein paclitaxel is distributed on the PEGylated folic acid targeting lactic acid / glycolic acid copolymer shell. The objective of the invention is to provide the Prussian blue-loaded targeting nanocomposite capable of realizing photoacoustic / magnetic resonance multi-mode imaging for implementation of image-guided treatment, comprehensive treatment of tumors and improvement of tumor treatment effect, and a preparation method thereof.

Description

technical field [0001] The invention relates to the field of polymer compounds, in particular to a targeting nanocomposite loaded with Prussian blue and a preparation method thereof. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, accounting for 7-10% of all kinds of malignant tumors in the whole body. It is the second leading cause of tumor-related death, second only to lung cancer, and seriously affects women's body and mind. Health and even life-threatening. Therefore, the diagnosis of breast cancer is particularly important, and the diagnosis of breast cancer depends on the development of imaging technology, and further affects the treatment and prognosis of breast cancer. Mammography is one of the most effective means of diagnosing breast cancer in recent years, but there is still a risk of radiation. Ultrasound and magnetic resonance (MRI) also play an important role in the diagnosis, staging, and follow-up of breast c...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/69A61K47/59A61K31/337A61K49/22A61K49/18A61K49/12A61P35/00
CPCA61K31/337A61K41/0052A61K49/0002A61K49/126A61K49/1857A61K49/225
Inventor 尚婷婷孙阳王志刚冉海涛李攀郑元义
Owner CHONGQING MEDICAL UNIVERSITY
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