Prussian blue-loaded targeting nanocomposite and preparation method thereof

A nanocomposite, Prussian blue technology, applied in the field of Prussian blue-loaded targeted nanocomposite and its preparation, can solve the problem of inability to combine photothermal therapy and chemotherapy comprehensive therapeutic effect, and achieve good photothermal conversion characteristics and photothermal properties. Thermal stability, good photothermal conversion ability, and the effect of improving therapeutic efficacy

Active Publication Date: 2017-08-04
CHONGQING MEDICAL UNIVERSITY
View PDF5 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a gap between PB NPs and ideal diagnostic and therapeutic nanoparticles, because the Prussian blue-based nanoparticles studied so far are all naked, without encapsulation or surface modification, and...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Prussian blue-loaded targeting nanocomposite and preparation method thereof
  • Prussian blue-loaded targeting nanocomposite and preparation method thereof
  • Prussian blue-loaded targeting nanocomposite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0052] The preparation method of the present invention carrying the Prussian blue targeting nanocomposite, the specific steps are as follows:

[0053] 1. Preparation of targeted nanocomposites loaded with Prussian blue

[0054] 1. Preparation of Prussian blue nanoparticles

[0055] a. Add 0.5mmol citric acid (98mg) to 20mL FeCl 3 (1.0mmol / L) aqueous solution, stirred at 60°C to obtain solution a;

[0056] b. Then, 20 mL of potassium ferrocyanide K containing an equivalent amount of 0.5 mmol citric acid 4 [Fe(CN) 6 ] (1.0mM) aqueous solution was added dropwise to the above solution a solution, a clear blue solution appeared, and stirred at 60°C for 1 minute;

[0057] c, the solution is cooled to room temperature, and then stirred at room temperature for 30 minutes to obtain a dispersion;

[0058] d. Add the same volume of 40mL acetone to the dispersion, and centrifuge at 28000rpm for 1 hour to form a precipitate of Prussian blue nanoparticles;

[0059] e. Prussian blue ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a Prussian blue-loaded targeting nanocomposite. The Prussian blue-loaded targeting nanocomposite comprises a PEGylated folic acid targeting lactic acid/glycolic acid copolymer shell coating Prussian blue nanoparticles, wherein paclitaxel is distributed on the PEGylated folic acid targeting lactic acid/glycolic acid copolymer shell. The objective of the invention is to provide the Prussian blue-loaded targeting nanocomposite capable of realizing photoacoustic/magnetic resonance multi-mode imaging for implementation of image-guided treatment, comprehensive treatment of tumors and improvement of tumor treatment effect, and a preparation method thereof.

Description

technical field [0001] The invention relates to the field of polymer compounds, in particular to a targeting nanocomposite loaded with Prussian blue and a preparation method thereof. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, accounting for 7-10% of all kinds of malignant tumors in the whole body. It is the second leading cause of tumor-related death, second only to lung cancer, and seriously affects women's body and mind. Health and even life-threatening. Therefore, the diagnosis of breast cancer is particularly important, and the diagnosis of breast cancer depends on the development of imaging technology, and further affects the treatment and prognosis of breast cancer. Mammography is one of the most effective means of diagnosing breast cancer in recent years, but there is still a risk of radiation. Ultrasound and magnetic resonance (MRI) also play an important role in the diagnosis, staging, and follow-up of breast c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K41/00A61K47/69A61K47/59A61K31/337A61K49/22A61K49/18A61K49/12A61P35/00
CPCA61K31/337A61K41/0052A61K49/0002A61K49/126A61K49/1857A61K49/225
Inventor 尚婷婷孙阳王志刚冉海涛李攀郑元义
Owner CHONGQING MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap