Nanometer flexible blood glucose microsensor and preparation method thereof

Abstract

The invention discloses a nanometer flexible blood glucose microsensor and a preparation method of the nanometer flexible blood glucose microsensor. The nanometer flexible blood glucose microsensor comprises a flexible substrate, an epoxy resin layer, an electrode structure and a glucose oxidase membrane layer, wherein the flexible substrate has the good temperature adaptability (-10 to 300 DEG C), the electrode structure has the excellent conductivity and can resist acid and alkaline corrosion, the glucose oxidase loaded microchannel (the length of the channel is smaller than 10mm, and the width of the channel is 10-500 [mu] m) is formed by the nanometer material texture, is good in flexibility and high in sensitivity, forms the linear dependence within the glucose concentration (0.5-30 mmol / L) range, and has the good invertibility and repeatability, and a hydrophilic wear-resistant film has the good ion penetrating property, strong water absorption property and the effect of protecting the sensitive layer. The nanometer flexible blood glucose microsensor is non-toxic and harmless, has the comfort in contacting the human skin and causes no allergy, the overall structure does not exceed 1cm<2>, and the in-situ real measurement and analysis for the blood glucose level (0.5-30 mmol / L) of the human blood can be realized through current response.

Description

technical field [0001] The invention belongs to the field of preparation of electrochemical sensors, and in particular relates to a nano-flexible blood sugar sensor and a preparation method thereof, which are used to realize in-situ real-time detection and analysis of human blood sugar, and ensure that the sensor is suitable for long-term wear and stable work of the human body, and can Realize non-invasive or minimally invasive blood sugar monitoring, and meet the wide-range blood sugar monitoring of diabetes. Background technique [0002] Blood sugar is closely related to human health. Long-term high blood sugar can cause various complications (such as uremia, limb necrosis, blindness, etc.), while low blood sugar can cause fainting, palpitation and weakness. Therefore, blood sugar testing is of great significance to human health. However, traditional blood glucose testing equipment is bulky and time-consuming, and cannot achieve real-time and accurate detection, which limi...

AI Technical Summary

Problems solved by technology

In terms of flexible sensor array design, Wei Gao et al. mentioned in the paper "Fully integrated wearable sensor arrays for multiplexed insituperspiration analysis" that flexible integrated sensor array design combines glucose, sodium and potassium ions, and pH value sensing microdevices in the same On flexible substrates, the design process is complicated, which is not conducive to the realization of mass production and manufacturing of products

Comprehensive consideration of the existing glucose sensors generally has a series of problems: 1. Low utility, complex structure design, large size, and difficult to realize portable and wearable functions; 2. The process is cumbersome and the device cost is too high; 3. The detection accuracy is low and difficult Realize real-time in-situ monitoring; 4. High requirements for the test environment; 5. The blood sugar response range is narrow, which is difficult to meet the monitoring of a wide range of blood sugar concentration in diabetic patients

Images