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Combination of biologically active substances for the treatment of hyperglycemic disorders

A technology for hyperglycemia and diseases, applied in the preparation of pharmaceutical compositions, compositions for treating and/or preventing hyperglycemia diseases, application in therapeutic foods and/or food supplements, in the field of therapeutic foods and food supplements, capable of solving Metabolic burden and other issues

Active Publication Date: 2020-09-25
百益康食品股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But excess sugar intake, especially if absorbed too quickly, places a heavy burden on metabolism and is considered a major risk factor for diabetes, overweight and obesity

Method used

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  • Combination of biologically active substances for the treatment of hyperglycemic disorders
  • Combination of biologically active substances for the treatment of hyperglycemic disorders
  • Combination of biologically active substances for the treatment of hyperglycemic disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1: Inhibition of LPH in vitro by quercetin derivatives and kaempferol derivatives

[0068] In vitro tests were performed on quercetin derivatives and kaempferol derivatives used as lactase phlorizin hydrolase (LPH) inhibitors. The test was performed according to the method of Amiri et al. (2012, J Inherit Metab Dis, 35(6):949-54). Here, human small intestine tissue (0.6 mg / ml) expressing LPH was used. Use phlorizin dihydrate as the substrate. The released glucose was measured using a standard assay (Chu & Cheung, 1978, Clin Biochem, 11(4):187-9).

[0069] result:

[0070] The tested quercetin derivatives and kaempferol derivatives showed high LPH inhibitory activity and were able to inhibit LPH in a concentration-dependent manner (Table 1). Quercetin-7-glucoside and kaempferol-7-O-glucoside showed particularly strong LPH inhibitory effects at a concentration of 50 mg / ml, inhibiting about 70%.

[0071]

[0072] Table 1: Inhibition of quercetin derivatives and kaempfe...

Embodiment 2

[0073] Example 2: The inhibitory effect of the combination of phloridin and LPH inhibitor on LPH / SGLT1

[0074] An in vitro model that simulates the situation in the human intestine was used to test the effect of the combination of phlorizin and LPH inhibitor on the uptake of glucose by SGLT1 transporter. The in vitro test model uses human small intestinal tissues that express lactase phlorizin hydrolase (LPH), which can cut phlorizin and other glycosides. Subsequently, the inhibitory effect of the reaction batch pretreated in this way on the SGLT1 transporter was determined in an in vitro experiment.

[0075] The human small intestine tissue expressing lactase phloside hydrolase (LPH) was prepared and used as described in Amiri and Naim (J Inherit Metab Dis (2012) 35:949-954). In short, the so-called "brush border membrane" is prepared from the small intestine, and the "brush border membrane" is incubated with phlorizin and / or the corresponding LPH inhibitor in a suitable buffer ...

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Abstract

The present invention relates to a synergistic composition comprising (a) phlorizin and (b) at least one more specifically defined inhibitor of the lactase-phlorizin hydrolase enzyme . More specifically, the present invention relates to such a composition for the treatment and / or prevention of hyperglycemic diseases, such as obesity, diabetes or secondary diseases caused by diabetes. The present invention also relates to the use of such compositions in the preparation of pharmaceutical compositions, curative foods and / or food supplements. Furthermore, the invention relates to pharmaceutical compositions, therapeutic foods and food supplements comprising the composition of the invention.

Description

Technical field [0001] The present invention relates to a synergistic composition comprising (a) phlorizin and (b) at least one further defined inhibitor of the lactase phlorizin hydrolase. Specifically, the present invention relates to a composition for the treatment and / or prevention of hyperglycemic diseases (such as obesity, diabetes or secondary diseases caused by diabetes). The invention also relates to the composition used in the preparation of pharmaceutical compositions and curative foods And / or food supplement application. The present invention also relates to pharmaceutical compositions, therapeutic foods and food supplements comprising the composition of the present invention. Background technique [0002] According to the Federal Statistics Office, the number of deaths from diabetes has increased by 29% since 1980. Therefore, the number of deaths caused by diabetes accounts for 3% of all deaths in Germany (2% in 1980). At the same time, the obese population in G...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10A61K31/7034
CPCA61K31/7034A61K31/7048A61K2300/00A61K31/352A61P3/04A61P43/00A61P3/10A23L33/10A23V2002/00
Inventor 亨宁·福勒特
Owner 百益康食品股份有限公司
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