Method for preparing specific protein composition

A specific, protein-based technology, applied in immunoglobulins, chemical instruments and methods, antiviral immunoglobulins, etc., to achieve the effect of low cost and simple production process

Inactive Publication Date: 2017-08-29
苏文全
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The main disadvantage of this process is that it requires two processes to prepare the globulin

Method used

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  • Method for preparing specific protein composition

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Embodiment Construction

[0008] 1. Preparation of the present invention

[0009] a: Vaccines for immunization: human tetanus vaccine and freeze-dried human rabies vaccine that meet the requirements of the Chinese Pharmacopoeia.

[0010] b: Plasma donor information: The plasma donor is the inventor himself, in good health, positive for hepatitis B virus surface antibody, gender: male, age at the time of specific immunization: 36 years old.

[0011] c: Specific immunization when preparing specific immune plasma in the first step:

[0012] Firstly, the plasma donors are vaccinated with the post-exposure immunization schedule of rabies vaccine on the 1st day (the same day), the 4th day, the 8th day, the 15th day and the 29th day; then the tetanus vaccine is given on the day of rabies vaccine immunization The same plasma donor is immunized according to the immunization schedule of the first day and the 29th day respectively, and the above-mentioned 29th day is called the last immunization day; On the fir...

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Abstract

The invention provides a method for synchronously preparing a specific protein composition from human hydrophobia immunoglobulin and human tetanus immunoglobulin. The method has the key points: firstly, immunizing the same blood plasma donor with a human tetanus vaccine and a human hydrophobia vaccine according to respective immunization schedules; collecting blood plasma after the last-time immunization; preparing the specific protein composition from the obtained specific immune blood plasma by adopting a blood-product immunoglobulin production method; adjusting the concentration of the specific protein composition in a manner that the valence of a human hydrophobia immunoglobulin antibody is not lower than 10IU/ml and the valence of a human tetanus immunoglobulin antibody is not lower than 4IU/ml. The method has the positive effects that the production process is simpler, and the cost is lower.

Description

technical field [0001] The invention relates to a preparation method of a medicine, in particular to a preparation method of a medicine for passive immunization and prevention of tetani infection of patients bitten or scratched by rabies or other mad animals. Background technique [0002] CN 105770890A discloses a specific protein composition, which is mainly composed of human rabies immunoglobulin and human tetanus immunoglobulin, and its preparation method is: human rabies immunoglobulin and human tetanus immunoglobulin are independently The preparation is obtained, and after passing the test, it is mixed according to the specified ratio to make a specific protein composition. The main disadvantage of this process is that it requires two processes to prepare the globulin. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a preparation method of a specific protein composition for simultaneous preparation of human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K39/42A61P31/04A61P31/14
CPCA61K2039/507A61K2039/545C07K16/10C07K16/1282
Inventor 苏文全
Owner 苏文全
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