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Application of bicyclol to preparation of diabetes drug

A technology for a diabetes drug and bicyclol is applied to the application field of bicyclol in the preparation of diabetes drugs, can solve problems such as toxic and side effects, cannot effectively prevent complications, etc., and achieve the effects of preventing liver disease, reducing fasting blood sugar level, and reducing blood lipids

Inactive Publication Date: 2017-09-01
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the treatment of diabetes mainly focuses on various hypoglycemic drugs and insulin therapy, but all of them have serious toxic and side effects, and none of them can effectively prevent the occurrence of complications

Method used

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  • Application of bicyclol to preparation of diabetes drug
  • Application of bicyclol to preparation of diabetes drug
  • Application of bicyclol to preparation of diabetes drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Using Type I Diabetes Animal Model to Detect Compounds

[0031] 1 Streptozotocin (STZ)-induced type I diabetes mouse model establishment and administration method

[0032]SPF-grade male ICR mice (20-22 g) were provided by the Experimental Animal Center of the Chinese Academy of Medical Sciences, and were bred in the GLP Animal Experiment Center of the Institute of Materia Medica, Chinese Academy of Medical Sciences. Free to eat and drink, the temperature is 20±3℃, the relative humidity is 50.0±10.0%, and the light is turned on every 12 hours. All operations in the experiment followed the Beijing Municipal Laboratory Animal Welfare Ethics Review Guidelines. The mice were fasted for 18 hours after adapting to the environment. Except for the mice in the blank control group, the rest of the mice were intraperitoneally injected with STZ 180mg / kg [STZ was dissolved in sodium citrate buffer (PH4.2-4.5), and prepared before use. ], and the mice in the blank control ...

Embodiment 2

[0055] Example 2 Utilize type II diabetes animal model to detect compound

[0056] 1 Establishment of type II diabetes animal model and administration method

[0057] SPF-grade male KKay mice (11 weeks old) were provided by the Experimental Animal Center of the Chinese Academy of Medical Sciences, and were bred in the GLP Animal Experiment Center of the Institute of Materia Medica, Chinese Academy of Medical Sciences. They were fed with high-fat feed (purchased from the Experimental Animal Center of Chinese Academy of Medical Sciences), free to eat and drink, the temperature was 20±3°C, the relative humidity was 50.0±10.0%, and the lights were turned on at intervals of 12 hours. All operations in the experiment followed the Beijing Municipal Laboratory Animal Welfare Ethics Review Guidelines. After the animals had adapted to the environment for 1 week, blood was taken from the tip of the tail, and the fasting blood glucose was measured with a Roche blood glucose meter for 4 h...

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Abstract

The invention discloses application of bicyclol as shown in the formula (I) to preparation of a drug for treating and / or preventing diabetes.

Description

technical field [0001] The present invention relates to a new medical application of bicyclol represented by formula (I), specifically the application of bicyclol in treating and / or preventing diabetes. [0002] Background technique [0003] Diabetes mellitus is a metabolic disordered endocrine disease caused by the interaction of genetic, environmental, immune and other factors. It is mainly marked by hyperglycemia and can be divided into type I diabetes and type II diabetes. Type I diabetes, also known as insulin-dependent diabetes mellitus, is a hyperglycemia disorder caused by the absolute lack of insulin caused by autoimmune damage and other causes of islet β-cell damage in the body. The symptoms of "three more and one less" are obvious. Type II diabetes is a disorder of glucose and lipid metabolism caused by decreased (relative lack) sensitivity to insulin in the body. It is characterized by hyperglycemia and hyperlipidemia, often accompanied by insulin resistance. ...

Claims

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Application Information

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IPC IPC(8): A61K31/36A61P3/10
CPCA61K31/36
Inventor 孙华张金兰刘宁张友文张丹
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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