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A kind of preparation technology of water-soluble Fangji extract

A preparation process and extract technology, which is applied in the preparation process of water-soluble Fangji extract, and in the field of preparation technology, can solve the problems of not being able to fully extract the effective ingredients of Fangji, affecting absorption, and low bioavailability, so as to improve the comprehensive utilization rate , The effect of improving water solubility

Active Publication Date: 2020-08-04
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the active ingredients of Fangji are not only alkaloids, but also flavonoid glycosides, sugars, etc. The applicant found that the method in this document cannot fully extract other active ingredients of Fangji, and there is still a lack of effective ingredients in Fangji. comprehensive extraction method
[0004] In addition, the active ingredients of Fangji are basically insoluble in water except flavonoid glycosides, so it is difficult to meet the production and application requirements of water-soluble preparations, and making other dosage forms will also affect the absorption of the human body, and the bioavailability is low, which affects the clinical application of Fangji medicinal materials

Method used

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  • A kind of preparation technology of water-soluble Fangji extract

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Comparison scheme
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Embodiment 1

[0026] A kind of preparation technology of water-soluble Fangji extract, concrete steps are as follows:

[0027] (1) Heat and reflux the Fangji medicinal material with 3 times the weight of ethanol aqueous solution with a volume concentration of 50% to extract twice, each extraction time is 1 hour, combine the extracts, filter, and concentrate the filtrate under reduced pressure to 0.5 times the weight of the medicinal material to obtain alcohol extract;

[0028] (2) The ethanol extract obtained in step (1) was heated and refluxed for 30 minutes with 5 times the weight of ethanol aqueous solution with a volume concentration of 30%, cooled to -5°C, allowed to stand for 12 hours, and filtered to remove insoluble impurities to obtain a filtrate;

[0029] (3) Add polyvinylpyrrolidone and polyethylene glycol 4000 to the filtrate sequentially while stirring, perform intermittent ultrasonic treatment for 20 to 30 minutes, and add water at 55°C at the beginning of each ultrasonic trea...

Embodiment 2

[0035] A kind of preparation technology of water-soluble Fangji extract, concrete steps are as follows:

[0036] (1) Heat and reflux the Fangji medicinal material with 5 times the weight of ethanol aqueous solution with a volume concentration of 60% to extract 3 times, each extraction time is 2 hours, combine the extracts, filter, and concentrate the filtrate under reduced pressure to 1 times the weight of the medicinal material to obtain alcohol extract;

[0037] (2) The ethanol extract obtained in step (1) was heated and refluxed with 8 times the weight of 40% ethanol aqueous solution by volume for 50 minutes, cooled to -5°C, allowed to stand for 24 hours, and filtered to remove insoluble impurities to obtain a filtrate;

[0038] (3) Add polyvinylpyrrolidone and polyethylene glycol 4000 to the filtrate sequentially while stirring, conduct intermittent ultrasonic treatment for 30 minutes, and add water at 60°C at the beginning of each ultrasonic treatment, and obtain ultrason...

Embodiment 3

[0044] A kind of preparation technology of water-soluble Fangji extract, concrete steps are as follows:

[0045] (1) Heat and reflux the medicinal material Fangji with 3 times the weight of ethanol aqueous solution with a volume concentration of 60% to extract twice, each extraction time is 2 hours, combine the extracts, filter, and concentrate the filtrate under reduced pressure to 0.5 times the weight of the medicinal material to obtain alcohol extract;

[0046] (2) The ethanol extract obtained in step (1) was heated and refluxed with 8 times the weight of ethanol aqueous solution with a volume concentration of 30 to 40% for 30 minutes, cooled to -5°C, left to stand for 24 hours, filtered to remove insoluble impurities, and the filtrate was obtained ;

[0047](3) Add polyvinylpyrrolidone and polyethylene glycol 4000 to the filtrate sequentially while stirring, conduct intermittent ultrasonic treatment for 20 minutes, and add water at 60°C at the beginning of each ultrasonic...

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Abstract

The invention discloses a preparation process of water-soluble fangji extract, which comprises four steps of first alcohol extraction, second alcohol extraction, intermittent ultrasonic treatment and intermittent microwave treatment. The preparation process of the present invention realizes the comprehensive extraction of various effective components such as isoquinoline alkaloids, flavonoid glycosides, phenols, volatile oils, organic acids and sugars in Fangji, and improves the comprehensive utilization rate of Fangji medicinal materials.

Description

technical field [0001] The invention relates to a preparation process, in particular to a preparation process of a water-soluble extract of Fangji. It belongs to the technical field of traditional Chinese medicine extraction. Background technique [0002] Fangji is distributed in many places in China, and it is mainly used to treat edema, beriberi, dysuria, and eczema sores. Fangjizhu contains isoquinoline alkaloids, flavonoid glycosides, phenols, volatile oils, organic acids and sugars, among which, isoquinoline alkaloids include tetrandrine (tetrandrine), demethylated tetrandrine, Fangchinoline (tetrandrine) and cylindrine, etc. Tetrandrine and fangchinoline have analgesic, anti-inflammatory, anti-allergic, blood pressure-lowering, coronary artery expansion effects, and also have anti-tumor effects. [0003] In the literature "Research on Extraction and Purification Process of Fangji Alkaloids" (Chinese Patent Medicine, 2014, 36 (6): 1306-1309), the extraction process o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/59
CPCA61K36/59A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 张薇
Owner SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY