Method for modifying leukocyte filtration membrane

A filter membrane and white blood cell technology, applied in the field of white blood cell filtration, can solve the problems of increasing the effective surface area of ​​the filter material in contact with blood, reducing the surface energy of the filter material and blood surface, increasing the wettability of the filter material, etc., to achieve obvious protection and stable properties , Improve the effect of surface wettability

Active Publication Date: 2017-09-08
广州达济医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the surface of the filter material is modified by surface grafting or coating with a hydrophilic polymer to increase the wettability of the filter material, reduce the surface energy of the filter material surface and blood, and increase the effective surface area of ​​the filter material in contact with blood. , thereby increasing the chances of capturing leukocytes
In addition, hydrophilic polymers are highly water-soluble, and there will be dissolution problems in blood

Method used

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  • Method for modifying leukocyte filtration membrane
  • Method for modifying leukocyte filtration membrane
  • Method for modifying leukocyte filtration membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 A kind of modification method of leukocyte filter membrane

[0031] The method for modifying the leukocyte filtration membrane comprises the steps of:

[0032] S1. Soak the polybutylene terephthalate nonwoven fabric filter membrane with polyoxyethylene lauryl ether solution for 24 hours, rinse once with ultrapure water, and then perform ultrasonic cleaning 3 times, each ultrasonic cleaning 10min, After finishing, place it in an oven at 80°C for drying;

[0033] S2. Soak the nonwoven fabric filter membrane treated in step S1 with a solution containing a photosensitizer, the bath ratio of the photosensitizer solution to the nonwoven fabric is 24:1, the soaking time is 18min, and the pressure is 5MPa; the photosensitizer The concentration of benzophenone in the solution is 0.15mol / L, and the concentration of 4,4'-bis(dimethylamino)benzophenone is 0.03mol / L; after soaking, high-energy ray irradiation is carried out under the protection of nitrogen flow. Accor...

Embodiment 2

[0037] Embodiment 2 A kind of modification method of leukocyte filter membrane

[0038] The method for modifying the leukocyte filtration membrane comprises the steps of:

[0039] S1. Soak the filter membrane of non-woven fabric with polyoxyethylene lauryl ether solution for 24 hours, rinse once with ultra-pure water, then perform ultrasonic cleaning, and dry in an oven at 80°C;

[0040] S2. Soak the non-woven fabric filter membrane treated in step S1 with a solution containing a photosensitizer, the bath ratio of the photosensitizer solution to the non-woven fabric is 24:1, the soaking time is 20min, and the pressure is 6.5MPa; The concentration of benzophenone in the photosensitizer solution is 0.16mol / L, and the concentration of 4,4'-bis(dimethylamino)benzophenone is 0.04mol / L; after soaking, the high-energy X-ray irradiation pretreatment for 10 minutes, the irradiation dose is 75kGy;

[0041] S3. Soak the non-woven fabric treated in step S2 with solution A again, the soa...

Embodiment 3

[0044] Embodiment 3 A kind of modification method of leukocyte filter membrane

[0045] The method for modifying the leukocyte filtration membrane comprises the steps of:

[0046] S1. Soak the filter membrane of non-woven fabric with polyoxyethylene lauryl ether solution for 24 hours, rinse once with ultra-pure water, then perform ultrasonic cleaning, and dry in an oven at 80°C;

[0047] S2. Soak the nonwoven fabric filter membrane treated in step S1 with a solution containing a photosensitizer, the bath ratio of the photosensitizer solution to the nonwoven fabric is 24:1, the soaking time is 15min, and the pressure is 3MPa; the photosensitizer The concentration of benzophenone in the solvent solution is 0.28mol / L, and the concentration of 4,4'-bis(dimethylamino)benzophenone is 0.08mol / L; after soaking, carry out high-energy radiation under the protection of nitrogen flow Irradiation pretreatment for 15 minutes, the irradiation dose is 75kGy;

[0048] S3. Soak the non-woven ...

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Abstract

The invention belongs to the technical field of leukocyte filtration and relates to a method for modifying a leukocyte filtration membrane. A cheap nonwoven fabric having acid and base resistance, corrosion resistance and high chemical stability is used as a base film material and is orderly subjected to two pretreatment processes, a double-component system of acrylic acid and sodium soyate is co-grafted to the treated fabric, and the double-component system undergoes a polymerization reaction under UV irradiation to produce a polymer containing a hydrophilic carboxyl group. The method has a high grafting rate, does not produce hemolysis phenomenon and has obvious protective effects on the red blood cells. The modified filter film has high interception effects on leukocytes and platelets in the whole blood.

Description

technical field [0001] The invention belongs to the technical field of leukocyte filtration, and in particular relates to a method for modifying a leukocyte filtration membrane. Background technique [0002] Blood contains plasma and blood cells. Blood cells can be divided into red blood cells, white blood cells and platelets. During the blood transfusion process, due to the reaction of the human immune system to foreign components, the white blood cells in the donor's blood and the white blood cell antibodies in the recipient's blood often cause hemolytic reactions. At the same time, there may be some virus infections related to white blood cells, such as giant Cellular virus, human immunodeficiency disease, etc. Therefore, in clinical medicine, the method of removing leukocytes during blood transfusion is often used to reduce these side effects. [0003] Existing studies have shown that platelets can also induce the body to produce anti-platelet antibodies. Antiplatele...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/78B01D67/00A61M1/02
CPCA61M1/0218B01D67/009B01D67/0093B01D71/78
Inventor 王衡东
Owner 广州达济医学科技有限公司
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