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A pharmaceutical composition for treating dry eye and/or corneal and conjunctival damage

A composition and drug technology, applied in the field of biomedicine, to achieve the effect of improving adverse reactions, good therapeutic effect, and improving intraocular pressure

Active Publication Date: 2019-09-17
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, NGF has not been combined with other known dry eye treatments and / or therapeutic agents (such as artificial tears, glucocorticoids, immunosuppressants, lacrimal gland stimulators (such as androgen tears), autologous serum, sex hormones, traditional Chinese medicine, etc. , especially glucocorticoid) combined in the treatment of dry eye, especially moderate to severe dry eye

Method used

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  • A pharmaceutical composition for treating dry eye and/or corneal and conjunctival damage
  • A pharmaceutical composition for treating dry eye and/or corneal and conjunctival damage
  • A pharmaceutical composition for treating dry eye and/or corneal and conjunctival damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 eye drops

[0042] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0043]

Embodiment 2

[0044] Embodiment 2 eye drops

[0045] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0046]

Embodiment 3

[0047] Embodiment 3 eye drops

[0048] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0049]

[0050]

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating xerophthalmia and / or cornea and conjunctiva damage. The pharmaceutical composition has the advantages that the pharmaceutical composition comprises NGF and glucocorticoid, the NGF and the glucocorticoid have a synergic effect, the pharmaceutical composition can evidently relieve the symptoms of the xerophthalmia and can be used for treating severe xerophthalmia especially the xerophthalmia with xerophthalmia severity being above 3 according to DEWS Report (2007) and / or cornea and conjunctiva damage, and the composition can also contain vitamin B to achieved a better curative effect; the pharmaceutical composition can also effectively improve the untoward effect of intraocular pressure rising caused by the glucocorticoid and can favorably lower the risk of glaucoma caused by intraocular pressure rising when the glucocorticoid is used for treating eye diseases.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a drug for treating dry eye and / or corneal and conjunctival damage, especially dry eye and / or corneal and conjunctival damage according to DEWS Report (2007) dry eye severity of 3 or more combination. Background technique [0002] Dry eye syndrome, also known as keratoconjunctivitis sicca, is a multifactorial disorder of the tear fluid and ocular surface that causes symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface, and This is accompanied by increased permeability of the tear film and inflammation of the ocular surface. Dry eye is considered a disorder of the lacrimal functional unit, a complete system of the lacrimal gland, ocular surface (cornea, conjunctiva, and meibomian glands), and eyelids, and the sensory and motor nerves connecting them. The lacrimal functional unit controls the major components of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61P27/02A61K31/573A61K31/51
Inventor 齐虹刘容均
Owner PEKING UNIV THIRD HOSPITAL
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