Medicine hydrate for treating dyspepsia and preparation method of medicine hydrate
A technology for indigestion and hydrate, which is applied in the field of medicine, can solve the problems that cannot be achieved, and achieve the effects of improving dissolution rate, improving bioavailability, yield and high purity
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Embodiment 1
[0060] Embodiment 1, the preparation of acotiamide hydrochloride hydrate
[0061] (1) under the sound field that frequency is 30KHz, output power is 50W, with the stirring velocity of 200 rev / mins, acotiamide hydrochloride crude product is added to volume be 6 times of acotiamide hydrochloride crude product weight while stirring. In the mixed solution of formamide and water, the volume ratio of formamide and water is 3.5:4.5, heat up and stir until dissolved;
[0062] (2) With the stirring speed of 200 revs / min, while stirring, add the n-butanol that volume is 3 times of acotiamide hydrochloride crude product weight;
[0063] (3) After adding n-butanol, under a sound field with a frequency of 20KHz and an output power of 15W, the temperature is lowered to 0-2°C at 3°C / hour, the crystal is grown for 4-6 hours, washed, and vacuum-dried to obtain albinohydrochloride Cotiamide hydrate 99.95g, yield 99.95%, purity 99.999%.
[0064] The X-ray powder diffraction spectrogram that th...
Embodiment 2
[0065] Embodiment 2, the preparation of acotiamide hydrochloride hydrate
[0066] (1) under the sound field that frequency is 25KHz, output power is 60W, with the stirring velocity of 260 revs / min, acotiamide hydrochloride crude product is added to the volume that is 5 times of acotiamide hydrochloride crude product weight while stirring. In the mixed solution of formamide and water, the volume ratio of formamide and water is 3.5:4.5, heat up and stir until dissolved;
[0067](2) With a stirring speed of 260 revs / min, adding volume while stirring is n-butanol that is 2 times of the crude product weight of acotiamide hydrochloride;
[0068] (3) After adding the n-butanol solution, under a sound field with a frequency of 15KHz and an output power of 20W, the temperature is lowered to 0-2°C at 2°C / hour, the crystal is grown for 4-6 hours, washed, and vacuum-dried to obtain hydrochloric acid Acotiamide hydrate 99.90g, yield 99.90%, purity 99.998%.
[0069] The X-ray powder diffr...
Embodiment 3
[0070] Embodiment 3, the preparation of acotiamide hydrochloride hydrate
[0071] (1) under the sound field that frequency is 25KHz, output power is 40W, with the stirring velocity of 150 rev / mins, acotiamide hydrochloride crude product is added to volume be 7 times of acotiamide hydrochloride crude product weight while stirring. In the mixed solution of formamide and water, the volume ratio of formamide and water is 3.5:4.5, heat up and stir until dissolved;
[0072] (2) With the stirring speed of 150 revs / min, while stirring, add the n-butanol that volume is 4 times of acotiamide hydrochloride crude product weight;
[0073] (3) After adding the n-butanol solution, under a sound field with a frequency of 15KHz and an output power of 10W, the temperature is lowered to 0-2°C at 4°C / hour, the crystal is grown for 4-6 hours, washed, and vacuum-dried to obtain hydrochloric acid Acotiamide hydrate 99.88g, yield 99.88%, purity 99.999%.
[0074] The X-ray powder diffraction spectru...
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