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A kind of porphyrin liposome radiopharmaceutical 99mtc-texaphyrin NPs and its preparation method

A radiopharmaceutical, 99mtc technology, used in in vivo radioactive preparations, radioactive physical shapes, radioactive carriers, etc.

Active Publication Date: 2018-07-06
PEKING UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no direct labeling method of 5N porphyrin-phospholipid liposomes using single-photon emitting nuclide, and there is no 5N porphyrin-phospholipid liposome radioactive label in the field of Single-Photon Emission Computed Tomography (SPECT). In vivo application in

Method used

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  • A kind of porphyrin liposome radiopharmaceutical 99mtc-texaphyrin NPs and its preparation method
  • A kind of porphyrin liposome radiopharmaceutical 99mtc-texaphyrin NPs and its preparation method
  • A kind of porphyrin liposome radiopharmaceutical 99mtc-texaphyrin NPs and its preparation method

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Embodiment 1

[0028] 1 Material:

[0029] Hydrogenated soybean phospholipids (HSPC) and cholesterol (Cholesterol) were purchased from Shanghai Avete Pharmaceutical Technology Co., Ltd. (AVT). Texas porphyrin phospholipids were provided by the Department of Medical Biophysics, University of Toronto. Distearoylphosphatidylethanolamine-polyethylene glycol 2000 was purchased from Avanti Polar Lipids, USA. Acetic acid and ammonium acetate were purchased from Sigma-Aldrich, USA. Tris (3-sulfonatophenyl) phosphine sodium salt (TPPTS) was purchased from China J&K Bailingwei Technology Co., Ltd. Na 99m TCO 4 Purchased from China Atomic Hi-Tech Co., Ltd.

[0030] 2 Methods and Results

[0031] 2.1 Radiochemical purity method

[0032] ITLC method: Agilent ITLC-SG silica gel glass fiber paper was selected and cut into rectangular paper strips with a length of 10 cm and a width of 1.5 cm. Spot the sample at 1 cm, unfold it with physiological saline solution, spread it to 9 cm, take out the paper...

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Abstract

The present invention discloses a porphyrin liposome radio pharmaceutical <99m>Tc-Texaphyrin NPs and a preparation method thereof, wherein the porphyrin liposome radio pharmaceutical <99m>Tc-Texaphyrin NPs comprises a nanometer material and a radionuclide <99m>Tc, the nanometer material is a liposome nanometer liposome formed from Texaphyrin-lipid, ie., Texahyrin NPs, and the radionuclide <99m>Tc label can achieve the self-labeling without the linking of any small molecule multifunctional chelating agents so as to form the<99m>Tc-Texaphyrin NPs. According to the present invention, the porphyrin liposome radio pharmaceutical <99m>Tc-Texaphyrin NPs can be concentrated into the tumor site having the EPR effect in the passive target manner, and can perform imaging diagnosis and detection on tumors or other diseases having the EPR effect by using the PET imaging technology of nuclear medicine.

Description

technical field [0001] The invention relates to radiopharmaceuticals for tumor diagnosis, in particular to a porphyrin liposome radiopharmaceutical 99m Tc-Texaphyrin NPs and its preparation method. Background technique [0002] Molecular probes are one of the core research contents of molecular imaging technology. In recent years, the research on molecular probes for different imaging modalities labeled with radionuclides, fluorescent dyes, paramagnetic and superparamagnetic materials, etc. has grown geometrically. Compared with traditional small-molecule probes, nano-molecular probes have the characteristics of integrating multiple functions and designs, drug packaging and delivery, long circulation time in vivo, and the ability to passively target tumors through the EPR (Enhanced Permeability and Retention effect), which can increase The anti-cancer effect of the drug and reduce the side effects. Based on the multifunctional properties of nano-molecular probes, a diagno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/12A61K51/04A61K103/10
CPCA61K51/0485A61K51/1234
Inventor 王凡史继云高翰男梁晓龙贾兵
Owner PEKING UNIV
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