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Composition with effect of promoting in-vivo lead removal

A composition and action technology, applied in the directions of drug combination, medical preparations containing active ingredients, application, etc., to achieve the effects of simple preparation method, scientific formulation, and reduced damage

Inactive Publication Date: 2017-10-20
SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, metal complexing agents are generally used to treat lead poisoning. Although the effect is good, there are certain side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 lead discharge function experiment

[0015] Animals and reagents: adult Kunming male mice, 20-24 g, provided by the Experimental Animal Center of Southern Medical University. Reagents: nitric acid (analytical grade, Kaifeng Kaihua Reagent Factory); lead acetate (analytical grade, Tianjin Tianda Chemical Experimental Factory); ethylenediaminetetraacetic acid disodium calcium salt (superior grade, Sinopharm Chemical Reagent Co., Ltd.).

[0016] Preparation of the test sample: 220g of grape seed extract, 120g of ginkgo biloba extract, 80g of aloe vera leaf freeze-dried powder, 1g of selenized carrageenan, and mix well.

[0017] experimental method:

[0018] (1) The high lead model in mice was established by intraperitoneal injection of lead acetate, injected once a day for 10 consecutive days, and the dose was 12 mg / kg·BW.

[0019] (2) The mice were randomly divided into 9 groups, 10 in each group, respectively blank control group, model control group, low dose...

Embodiment 2

[0026] Example 2 Lead Expelling Functional Prescription Screening Experiment

[0027] Composition 1: Take 240 grams of grape seed extract, 140 grams of ginkgo leaf extract, 100 grams of aloe vera leaf freeze-dried powder, and 1 gram of selenized carrageenan, grind them evenly, mix them evenly, and set aside.

[0028] Composition 2: 200 grams of grape seed extract, 100 grams of ginkgo biloba extract, 60 grams of freeze-dried aloe vera leaf powder, and 1 gram of selenized carrageenan, ground and mixed evenly, and set aside.

[0029] Composition 3: 220 grams of grape seed extract, 120 grams of ginkgo biloba extract, 80 grams of freeze-dried aloe vera leaf powder, and 1 gram of selenized carrageenan, grind well, mix well, and set aside.

[0030] experimental method:

[0031] The experiment was carried out according to the method of Example 1, and the mice were randomly divided into 5 groups, 10 in each group, respectively blank control, model control, and composition 1-3 groups. ...

Embodiment 3

[0036] The preparation of embodiment 3 composition capsules and tablet

[0037] Take 220g of grape seed extract, 120g of ginkgo biloba extract, 80g of aloe whole leaf freeze-dried powder, and 1g of selenized carrageenan, mix well, add 140g of starch, mix well, granulate, granulate, dry, add 0.5% Micropowder silica gel and 0.5% magnesium stearate are mixed evenly, and packed into capsules according to the loading amount of 0.5 g / grain, so as to obtain the composition capsule.

[0038] Take 220g of grape seed extract, 120g of ginkgo biloba extract, 80g of aloe whole leaf freeze-dried powder, and 1g of selenized carrageenan, mix well, add 140g of starch, mix well, granulate, granulate, dry, add 0.5% Micropowder silica gel and 0.5% magnesium stearate are mixed evenly, and compressed into tablets according to the specification of 0.5 g / tablet to obtain the composition tablet.

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PUM

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Abstract

The invention discloses a composition with an effect of promoting in-vivo lead removal. The composition is prepared from the following raw materials in parts by weight: 200 to 240 parts of grape pip extract, 100 to 140 parts of ginkgo leaf extract, 60 to 100 parts of aloe leaf freeze-dried powder and 1 part of selenium carrageenancarrageenan selenide. Compared with the prior art, the composition is scientific in prescription; polyphenol compounds in components exert a synergistic reaction; the lead removal effect is obvious in obvious and safe, and has no side effects; further, a preparation method is simple; the industrialized production can be realized.

Description

technical field [0001] The invention relates to a composition with the effect of promoting lead excretion in the body. Background technique [0002] Lead is a blue-gray heavy metal that cannot be degraded. It exists in the environment for a long time and has strong potential toxicity to many living organisms. Therefore, lead has always been listed as a strong pollutant. Lead ingestion into the human body will damage the human bone marrow hematopoietic system, nervous system and male reproductive gland system. [0003] There are many causes of lead poisoning, including industrial pollution such as printing, smelting, shipbuilding, machinery manufacturing, and batteries. Excessive use of pesticides, use of lead materials and the widespread existence of lead dust have also aggravated the lead pollution of food and drinking water. Daily foods such as preserved eggs, popcorn, and canned foods often contain trace amounts of lead; according to investigations, the blood lead level...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/886A61K36/896A61P39/02A23L33/105A23L19/00A23L29/256A61K31/737
CPCA23L19/01A23L29/256A23L33/105A23V2002/00A61K31/737A61K36/16A61K36/87A61K36/886A61K36/896A61K2300/00A23V2250/21A23V2250/5036A23V2200/30
Inventor 王永刚彭维马国标张伟健林青薇
Owner SUN YAT SEN UNIV
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