Application of sinomenine in preparation of drug for treating photosensitive dermatitis

A photosensitivity and sinomenine technology, applied in the direction of drug combination, skin diseases, etc., can solve the problems of complex ingredients, drug safety threats, etc., and achieve the effect of low toxicity and obvious therapeutic effect

Inactive Publication Date: 2017-10-24
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the chemical composition of Tripterygium wilfordii is complex, and it has strong toxicity to the heart, liver, kidney and reproductive system, and there are many factors affecting its tox

Method used

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  • Application of sinomenine in preparation of drug for treating photosensitive dermatitis
  • Application of sinomenine in preparation of drug for treating photosensitive dermatitis
  • Application of sinomenine in preparation of drug for treating photosensitive dermatitis

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Embodiment Construction

[0028] The implementation of the present invention will be described in detail below with examples, so as to fully understand and implement the implementation process of how the present invention uses technical means to solve technical problems and achieve technical effects.

[0029] The invention discloses an application of sinomenine in the preparation of a medicament for treating photosensitive dermatitis.

[0030] Specifically, sinomenine is prepared into tablets, pills, oral liquids and the like with auxiliary materials.

[0031] The technical effect of the present invention is illustrated below in conjunction with concrete experimental data:

[0032] 1. The effect of sinomenine on the pathomorphology and expression of TSLP in the treatment of photosensitive dermatitis

[0033] 1) Experimental method:

[0034] 1. Animals and grouping: 24 Balb / c mice, weighing 20±2g, half male and half male, were randomly divided into 4 groups (contact photosensitive dermatitis control g...

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Abstract

The invention discloses application of sinomenine in preparation of a drug for treating photosensitive dermatitis. The drug disclosed by the invention has an obvious effect for treating the photosensitive dermatitis. The treatment effect of the drug disclosed by the invention on the photosensitive dermatitis is closely related to the effect of decreasing TSLP (Thymic stromal lymphopoietin)-DCs induced T-lymphocyte toxic damage.

Description

technical field [0001] The invention belongs to the field of drug research and development, and in particular relates to the application of sinomenine in the preparation of drugs for treating photosensitive dermatitis. Background technique [0002] Photoallergic dermatitis (photoallergic dermatitis) is a relatively common skin disease caused or aggravated by ultraviolet radiation in the sun. Most patients with photosensitive dermatitis have a history of photosensitivity, usually 1-2 days after sun exposure, manifested as small papules and vesicles on the face, neck and front of the neck, and small papules and blisters on the extensor sides of the upper limbs. Those who can show eczema-like changes. Photosensitive dermatitis can be divided into contact photosensitive dermatitis and systemic photosensitive dermatitis according to the scope of lesions. If it is not treated in time and effectively, it can develop into chronic photosensitive dermatosis. Systemic photosensitive ...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61P17/00
CPCA61K31/485
Inventor 杨仁华陈鹏沈志强马丽花张小超何波
Owner KUNMING MEDICAL UNIVERSITY
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