Method for extracting and separating nux vomica total alkaloids from nux vomica

A technology of total alkaloids and nuxychonzi, which is applied in the field of medicine to achieve the effects of short production cycle, simple and convenient preparation process and low cost

Inactive Publication Date: 2017-10-24

XIANGTAN UNIV

7 Cites 4 Cited by

AI-Extracted Technical Summary

Problems solved by technology

The method of extracting strychnium alkaloids from strychnium is usually the heat reflux extraction m...

Abstract

The invention relates to a method for extracting and separating nux vomica total alkaloids from nux vomica. In the method, coarse powder of nux vomica is subjected to extraction through a flash extraction process; then a nux vomica extract liquid is concentrated and alkalized, and is filtered to remove precipitates; the filtrate then is purified through macroporous adsorption resin to obtain the nux vomica total alkaloids, in which content of strychnine is significantly reduced. The method has simple operations, is energy-saving and environment-friendly, and is free of residual toxic solvents in the product. Majority of strychnine in the produced nux vomica total alkaloids is removed, so that the product is reduced in toxicity and enhanced in curative effects.

Application Domain

Plant ingredients

Technology Topic

SolventToxicity +7

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Examples

Experimental program(9)

Example Embodiment

[0020] Example 1:

[0021] Weigh 50.0g of rough powder of strychoma and place it in a round bottom flask, add 400ml of 50% ethanol for the first time, extract for 2h by hot reflux method, filter, add 300ml of 50% ethanol for the second time, extract 1.5h by hot reflux method, Add 200ml of 50% ethanol for the third time, extract for 0.5h by hot reflux method, filter, combine the three filtrates, use HPLC to detect the concentration of the extract in the filtrate and calculate the extraction rate. The filtrate is concentrated to a constant weight to calculate the extract rate.

Example Embodiment

[0022] Example 2:

[0023] Weigh 50.0g of crude strychoma powder and place it in a round-bottomed flask, add 400ml of 50% ethanol for the first time, extract 1h with ultrasonic assisted extraction, filter, add 300ml of 50% ethanol for the second time, extract 0.5 by ultrasonic assisted extraction h, filter, add 200ml of 50% ethanol for the third time, extract for 0.5h with ultrasonic assisted extraction, filter, combine the three filtrates, use HPLC to detect the concentration of the extract in the filtrate and calculate the extraction rate. The filtrate is concentrated to a constant weight, and the leaching is calculated Paste rate.

Example Embodiment

[0024] Example 3:

[0025] Weigh 50.0g of crude strychoma powder, place it in a flash extractor, add 400ml of 50% ethanol for the first time, flash for 2min, and filter, and add 300ml of 50% ethanol for the second time, flash for 1min, filter, and third Add 200ml of 50% ethanol every time, flash for 1min, filter, combine the three filtrates, use HPLC to detect the concentration of the extract in the filtrate and calculate the extraction rate. The filtrate is concentrated to a constant weight to calculate the extract rate.

[0026] Table 1 The effect of different extraction methods on the extraction rate of active ingredients and extract rate

[0027]

[0028] Conclusion: It can be seen from Table 1 that the flash extraction method has the lowest extract rate among the three methods. The extraction rate of strychnine and strychnine and strychnine extracted by heat reflux extraction for 4.5 hours and ultrasonic wave 2h extraction are similar, while the extraction rate for flash extraction method is 4 minutes. The extraction rate is higher than the previous two methods, and the extraction rate of strychnine and strychnine can reach more than 80%, which reflects the high efficiency and rapidity of flash extraction.

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Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

Short production cycle
low cost

Method for extracting and separating nux vomica total alkaloids from nux vomica

A technology of total alkaloids and nuxychonzi, which is applied in the field of medicine to achieve the effects of short production cycle, simple and convenient preparation process and low cost

AI-Extracted Technical Summary

Problems solved by technology

Abstract

Image

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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