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Method for extracting and separating nux vomica total alkaloids from nux vomica

A technology of total alkaloids and nuxychonzi, which is applied in the field of medicine to achieve the effects of short production cycle, simple and convenient preparation process and low cost

Inactive Publication Date: 2017-10-24
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method of extracting strychnium alkaloids from strychnium is usually the heat reflux extraction method, so far no flash extraction method has been used to extract strychnium alkaloids from strychnium

Method used

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  • Method for extracting and separating nux vomica total alkaloids from nux vomica
  • Method for extracting and separating nux vomica total alkaloids from nux vomica
  • Method for extracting and separating nux vomica total alkaloids from nux vomica

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 50.0g of Nuxychnium seed coarse powder, put it in a round bottom flask, add 400ml of 50% ethanol for the first time, extract by heat reflux method for 2h, filter, add 300ml of 50% ethanol for the second time, extract by heat reflux method for 1.5h, Add 200ml of 50% ethanol to the third filtration, heat reflux extraction for 0.5h, filter, combine the three filtrates, use HPLC to detect the concentration of the extract in the filtrate and calculate the extraction rate, concentrate the filtrate to constant weight, and calculate the extract rate.

Embodiment 2

[0023] Weigh 50.0g of Nuxychnium seed coarse powder, put it in a round bottom flask, add 400ml of 50% ethanol for the first time, extract for 1h with ultrasonic-assisted extraction, filter, add 300ml of 50% ethanol for the second time, extract 0.5ml with ultrasonic-assisted extraction h, filter, add 50% ethanol 200ml for the third time, extract 0.5h by ultrasonic-assisted extraction, filter, combine the filtrate three times, detect the concentration of the extract in the filtrate with high performance liquid phase and calculate the extraction rate, concentrate the filtrate to constant weight, and calculate the extraction rate. ointment rate.

Embodiment 3

[0026] Table 1 Effects of different extraction methods on the extraction rate and extract rate of active ingredients

[0027]

[0028] Conclusion: From Table 1, we know that the extraction rate of the flash extraction method is the lowest among the three methods, and the strychnine and strychnine extracted by heat reflux extraction for 4.5h and ultrasonic wave for 2h have similar extraction rates, while the extraction rate of strychnine and strychnine extracted by the flash extraction method for 4min The extraction rate is higher than that of the first two methods, and the extraction rate of strychnine and strychnine can both reach more than 80%, reflecting the advantages of high efficiency and rapidity of flash extraction.

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Abstract

The invention relates to a method for extracting and separating nux vomica total alkaloids from nux vomica. In the method, coarse powder of nux vomica is subjected to extraction through a flash extraction process; then a nux vomica extract liquid is concentrated and alkalized, and is filtered to remove precipitates; the filtrate then is purified through macroporous adsorption resin to obtain the nux vomica total alkaloids, in which content of strychnine is significantly reduced. The method has simple operations, is energy-saving and environment-friendly, and is free of residual toxic solvents in the product. Majority of strychnine in the produced nux vomica total alkaloids is removed, so that the product is reduced in toxicity and enhanced in curative effects.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a method for extracting and purifying effective components of traditional Chinese medicines, in particular to a method for extracting and separating total alkaloids of Nuxychnium chinensis. Background technique [0002] Nuxychia, also known as Pangezi, is a commonly used highly toxic traditional Chinese medicine. It was first recorded in "Compendium of Materia Medica". It has a good clinical curative effect on various pain symptoms such as rheumatic joint pain. The main active ingredient of Strychnium is indole alkaloids, in which strychnine and strychnine are more than 80% of the total amount of Strychnine alkaloids. The content of strychnine is the highest, and the Pharmacopoeia stipulates that it contains 12-22mg / g, accounting for about 40-50% of the total alkaloids; followed by strychnine, which is not less than 8mg / g in the Pharmacopoeia, accounting for about 30% of the tot...

Claims

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Application Information

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IPC IPC(8): A61K36/56
CPCA61K36/56A61K2236/333A61K2236/53A61K2236/55
Inventor 汤淮波何丽丽杨薇符艳
Owner XIANGTAN UNIV
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