Modified xanthan gum nano-micelle preparation method
A technology of nano-micelle and nano-micelle solution, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. It can improve the drug release time, enhance the antioxidant performance, and be less prone to oxidative degradation.
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[0031] Example 1
[0032] 1-1) Synthesis of amphiphilic modified xanthan gum polymer modified by phthalic anhydride:
[0033] Dissolve 2g of xanthan gum in 200mL of deionized water, stir it evenly, add 0.06g of 4-dimethylaminopyridine, and slowly add 20mL of acetone solution with 0.5g of phthalic anhydride to the xanthan gum solution. Stir evenly, heat to 60℃ for 12h, then cool to room temperature, precipitate with 3 times the volume of ethanol, filter, wash the precipitate with ethanol three times, and vacuum dry at 60℃ to constant weight to obtain phthalic anhydride modified xanthogen Glue crude product; dissolve the crude product with deionized water, configure it as a 0.5w% solution, and transfer it to a dialysis bag with a molecular weight cut-off of 14000. The deionized water is the external dialysis fluid. The external dialysis fluid is changed every 5 hours. In less than 72 hours, remove unreacted small molecules and catalysts, freeze-dry the dialysis sample to obtain amph...
Example Embodiment
[0038] Example 2
[0039] As shown in Example 1-1), an aqueous solution of xanthan gum was prepared, the same amount of catalyst was added, and 20 mL of acetone solution dissolved in 1.0 g of phthalic anhydride was slowly added dropwise to the xanthan gum solution, stirred evenly, and heated After reacting at 60°C for 12 hours and cooling to room temperature, the post-treatment is as in Example 1-1), the modified xanthan gum nanomicelles are prepared as in Example 1-2), and the drug-loaded modified xanthan gum nanomicelles are prepared as in the implementation Example 1-3), the obtained modified xanthan gum nanomicelles are denoted as XP2.
Example Embodiment
[0040] Example 3
[0041] As shown in Example 1-1), an aqueous solution of xanthan gum was prepared, the same amount of catalyst was added, and 20 mL of acetone solution dissolved in 2.0 g of phthalic anhydride was slowly added dropwise to the xanthan gum solution, stirred evenly, and heated After reacting at 60°C for 12 hours and cooling to room temperature, the post-treatment is as in Example 1-1), the modified xanthan gum nanomicelles are prepared as in Example 1-2), and the drug-loaded modified xanthan gum nanomicelles are prepared as in the implementation Example 1-3), the obtained modified xanthan gum nanomicelles are denoted as XP3.
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