Three-dimensional SERS (surface enhanced raman scattering) substrate based on macromolecular brush/metal nanometer particle composite film and preparation method thereof

A technology of metal nanoparticles and polymer brushes, which is applied in the field of three-dimensional SERS substrates and its preparation, can solve the problems of low nanoparticle content and limit the sensitivity of SERS substrates, and achieve strong Raman enhancement characteristics, excellent sensitivity and stability , the effect of convenient operation

Inactive Publication Date: 2017-11-07
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Problems solved by technology

This method is very common in the construction of SERS substrates. However, the steric hindrance effect of polymer brushes will lead to less attached nanoparticles, and can only form a two-dimensional structure with particles distributed on the surface, which greatly limits Sensitivity of SERS substrates

Method used

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  • Three-dimensional SERS (surface enhanced raman scattering) substrate based on macromolecular brush/metal nanometer particle composite film and preparation method thereof
  • Three-dimensional SERS (surface enhanced raman scattering) substrate based on macromolecular brush/metal nanometer particle composite film and preparation method thereof
  • Three-dimensional SERS (surface enhanced raman scattering) substrate based on macromolecular brush/metal nanometer particle composite film and preparation method thereof

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Embodiment 1

[0032] A method for preparing a three-dimensional SERS substrate based on a polymer brush / metal nanoparticle composite film, comprising the following steps:

[0033] (1) Preparation of metal nanoparticles solution

[0034] Taking silver nanoparticles as an example, the preparation method is: add 1% silver nitrate solution to 1% sodium citrate and water, keep at 70°C for 10 minutes, then quickly add 0.1% sodium borohydride solution, the solution immediately turns bright yellow, After keeping for 1 h, it was cooled to room temperature, and the resulting solution was used as a seed. Afterwards, add 1% sodium citrate solution into 80 mL of water, heat to boiling for 15 minutes, then add the above seeds and 1% silver nitrate solution, keep boiling for 1 hour, then cool to room temperature. Repeat the above steps once more to prepare the silver nanoparticle solution. The size of the prepared silver nanoparticles is about 26nm.

[0035] (2) Preparation of POEGMA brushes

[0036] ...

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Abstract

The invention discloses a three-dimensional SERS (surface enhanced raman scattering) substrate based on a macromolecular brush/metal nanometer particle composite film and a preparation method thereof. The preparation method of the substrate comprises the following steps of soaking POEGMA brushes into a metal nanometer particle solution for 20min to 12h; performing rinsing for multiple times by ultrapure water; performing drying through blowing by N2; then, soaking the POEGMA brushes into a metal nanometer particle solution; repeatedly performing the soaking-rinsing-blow drying-soaking process for 1 to 36 times; through a layer-by-layer stacking principle, compounding the nanometer particles into the macromolecular brushes by using the replacement effect of the EG groups of the POEGMA and citrates on the surface of the metal nanometer particles. The substrate is particularly applicable to the detection of micromolecular biological markers and bacterial detection. The preparation method provided by the invention is simple; the implementation is easy; the operability is high. The prepared SERS substrate has low cost, high Raman enhancement characteristics, excellent sensitivity and excellent stability.

Description

technical field [0001] The invention relates to the fields of functional material preparation and Raman detection, in particular to a three-dimensional SERS substrate based on a polymer brush / metal nanoparticle composite film and a preparation method thereof. Background technique [0002] Surface Enhanced Raman Scattering (SERS) refers to the phenomenon that the inherent Raman signal of molecules adsorbed on a rough metal surface is greatly enhanced, and its enhancement factor can reach 14-16 orders of magnitude. SERS has been widely used in molecular monitoring and analysis in the fields of chemistry, biology, medicine, food, and environment because of its high detection sensitivity, fingerprint detection characteristics, short measurement time, simple pretreatment, and no interference from water environments. The enhancement mechanism of SERS is mainly due to the enhancement caused by the interaction between the local electromagnetic field generated by the plasmon oscillat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65B82Y30/00B82Y15/00
CPCG01N21/658B82Y15/00B82Y30/00
Inventor 褚立强张倩王向东
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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