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Mechanical device for generating animal hyperplastic scars

A technology of hypertrophic scars and mechanical devices, applied in the field of biomedical experiments, can solve the problems of slow progress in in vivo research, and achieve the effect of high authenticity and simple structure

Pending Publication Date: 2017-11-24
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, rodents, which are widely used to establish animal models, do not produce obvious hypertrophic scars after trauma, so the in vivo research on the mechanism of hypertrophic scars is progressing slowly

Method used

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  • Mechanical device for generating animal hyperplastic scars
  • Mechanical device for generating animal hyperplastic scars
  • Mechanical device for generating animal hyperplastic scars

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] Such as figure 1 Shown is a mechanical device for generating hypertrophic scars in animals, including a skin testing mechanical scaffold for measuring the tension the skin bears and a scar manufacturing scaffold for establishing hypertrophic scars according to the tested tension.

[0021] Such as figure 2 As shown, the mechanical support for skin testing includes two skin supports 1, two force-measuring connecting blocks 3 and a force-measuring screw 4; the two skin supports 1 are arranged symmetrically; one force-measuring connecting block 3 is combined with the corresponding A skin support 1 is connected; two force-measuring connecting blocks 3 middle parts are provided with through holes, the through-holes of the first force-measuring connecting block are threaded holes, and the through-holes of the second force-measuring connecting block are smooth holes; force-measuring screw rod 4 Through the through holes of the two force-measuring connecting blocks 3 in turn, ...

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PUM

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Abstract

The invention discloses a mechanical device for generating animal hyperplastic scars. The mechanical device comprises a skin testing mechanical support and a scar making support, wherein the skin testing mechanical support is used for measuring skin bearing tension, and the scar making support is used for building the hyperplastic scars according to the tested tension. The scar making support comprises two symmetric skin supports, two force application connecting blocks and a rotating screw, a fixing hole combined with skin is formed in each skin support, one force application connecting block is connected with the corresponding skin support through a fixing hoop combination, threaded holes in opposite thread directions are formed in the two force application connecting blocks, the rotating screw is sequentially connected with the two force application connecting blocks in a threaded manner, sliding rods are arranged on two sides of the rotating screw, and the force application connecting blocks can slide along the sliding rods. The mechanical device can continuously apply a certain mechanical stress to a laboratory rodent healing wound, and natural tension of human skin is simulated.

Description

technical field [0001] The invention belongs to the technical field of biomedical experiments, and relates to a mechanical device for generating animal hypertrophic scars. Background technique [0002] Hypertrophic scars often occur after burns, and the incidence rate is high in my country. Because the mechanism of its occurrence is still unclear, there is no effective prevention and treatment method. Therefore, it is urgent to establish animal models to study the pathogenesis of hypertrophic scar. However, rodents, which are widely used to establish animal models, do not produce obvious hypertrophic scars after trauma, so the in vivo research on the mechanism of hypertrophic scars is progressing slowly. It has been reported in the literature that the tension of skin and other tissues is an important factor affecting the occurrence of hypertrophic scars, and rodent experimental animals belong to loose skin animals, and their skin tension is much smaller than that of humans....

Claims

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Application Information

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IPC IPC(8): A61D1/00G01L5/00
CPCG01L5/00A61D1/00Y02A40/70
Inventor 苏映军马显杰杨宽
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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