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A kind of synthetic method of graphene oxide nano-silver

A synthesis method, nano-silver technology, applied in the field of tumor cells, to achieve good results, environmental friendliness, and simple operation

Active Publication Date: 2019-06-25
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on loading silver nanoparticles on the surface of graphene is mostly based on the liquid phase reduction method, but most of the preparation process inevitably introduces biological toxicity and environmental hazard reagents (such as sodium borohydride, formaldehyde, hydroquinone, etc. )

Method used

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  • A kind of synthetic method of graphene oxide nano-silver
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  • A kind of synthetic method of graphene oxide nano-silver

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Experimental program
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Embodiment Construction

[0015] First, 2g of natural graphite was added to 350mL of sulfuric acid at 0°C, and then 8g of potassium permanganate and 1g of sodium nitrate were slowly added to dissolve, while stirring. The solution was stirred in a 40 °C water bath for 1 h. Slowly add 250mL deionized water, 98°C, 30min. Add 500mL deionized water and 40mL 30% hydrogen peroxide to terminate the reaction. At this time, it can be observed that the solution turns orange, which can prove that the product is graphene oxide. 0.2M hydrochloric acid was added to remove metal ions from the solution. Add deionized water and stir, let stand for 10 minutes, discard the supernatant, repeat several times until the solution is neutral (pH7). The product was sonicated for 2 h and freeze-dried for later use.

[0016] 100mg of graphene oxide was dissolved in 60mL of deionized water, ultrasonically treated for 1h, 30mL of 1mM silver nitrate was added, 10mL of 1mM quercetin was added quickly, and stirred at 90°C for 12h. ...

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Abstract

The invention relates to the field of biomedicine, in particular to a method for synthesizing graphene oxide nano-silver. The method comprises the following steps: the natural graphite is mixed with sulfuric acid, potassium permanganate and sodium nitrate to obtain graphite oxide; the graphite oxide is mixed with silver nitrate and quercetin to obtain a graphene oxide nano-silver composite material. The method of the invention is simple to operate, and the synthesized graphene oxide nano-silver can be used as an anti-tumor substitute drug and overcome drug resistance of tumors.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a method for synthesizing graphene nano-silver by using quercetin, which is applied to treating tumor cells such as neuroblastoma cells. Background technique [0002] Graphene, in addition to its large specific surface area and high chemical stability, also has a regular planar two-dimensional structure and excellent adsorption capacity, which makes it an ideal carrier for loading silver nanoparticles and constructing new antibacterial agents. Anticancer system. As a traditional antibacterial agent, silver has become an important inorganic antibacterial agent and the development direction of antitumor research because of its anti-tumor, broad antibacterial spectrum, low drug resistance and high safety. In the composite material prepared by graphene oxide and nano-silver, graphene oxide uses its rich polar functional groups to fix the nano-silver particles on the sheet structure, which...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K33/38A61P35/00A61P31/04B22F9/24B22F1/00B82Y30/00B82Y40/00C01B32/198
CPCA61K47/02A61K33/38B82Y30/00B82Y40/00B22F9/24B22F1/07B22F1/054B22F1/068
Inventor 袁玉国钟平
Owner YANGZHOU UNIV