Bioactive bracket with bionic lotus-root structure, and preparation method and application thereof

A biologically active, bionic lotus root technology, applied in tissue regeneration, prosthesis, medical science, etc., can solve problems such as low porosity, restriction of new blood vessels and new bone tissue growth, unfavorable nutrition and cell transmission, etc., to achieve improved Effect of Porosity and Specific Surface Area

Active Publication Date: 2017-12-08
中科硅诺(太仓)生物材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional 3D printed bioscaffolds are made of solid primitives stacked layer by layer. Except for the macroscopic macropores between the primitives, the primitives are solid structures with relatively low porosity, and pores cannot form. The pipeline structure is not conducive to the transmission of nutrients and cells to the inside of the scaffold during surgery, thereby limiting the growth of new blood vessels and new bone tissue[9-11]

Method used

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  • Bioactive bracket with bionic lotus-root structure, and preparation method and application thereof
  • Bioactive bracket with bionic lotus-root structure, and preparation method and application thereof
  • Bioactive bracket with bionic lotus-root structure, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 1

[0080] Embodiment 1 The preparation of one channel bionic lotus root support (1CSP) nozzle:

[0081] (1) A cylindrical steel needle with a diameter of 600 μm is embedded in parallel in the traditional No. 22 3D printing nozzle to ensure that the heads of the steel needle and the traditional nozzle do not touch each other and the distance is the same;

[0082] (2) 50g feldspar ceramic powder, 400 rpm planetary ball mill for 5 hours, the powder after ball milling was passed through 200 mesh sieve;

[0083] (3) Weighing 3.5g feldspar ceramic powder, 0.15g sodium alginate powder and 1.8g binder F127 (20wt%) are fully mixed to form a toothpaste-like slurry;

[0084] (4) Install the nozzle prepared in step 1, and print out a channel magnesian feldspar bionic lotus root support green body;

[0085] (5) The stent green body was sintered at 1350°C for 3 hours to obtain a one-channel biomimetic lotus root 3D printed stent.

Embodiment 2

[0086] The preparation of embodiment 2 dual-channel bionic lotus root support (2CSP) nozzle:

[0087] It is basically the same as Example 1, except that in step (1), two cylindrical steel needles with a diameter of 600 μm are embedded in parallel inside the traditional No. 22 3D printing nozzle, ensuring that the two steel needles and the head of the traditional nozzle are free touch each other and have the same spacing.

Embodiment 3 3

[0088] Embodiment 3 The preparation of the three-channel bionic lotus root support (3CSP) nozzle:

[0089] It is basically the same as Example 1, except that in step (1), three cylindrical steel needles with a diameter of 600 μm are inlaid in parallel inside the traditional No. 22 3D printing nozzle to ensure that the heads of the three steel needles and the traditional nozzle do not touch each other and the same spacing.

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Abstract

The invention relates to a bioactive bracket with a bionic lotus-root structure, and a preparation method and an application thereof. The bioactive bracket is formed by stacking of compositional elements, wherein each compositional element is internally provided with one or more parallel channels. The bioactive bracket has the bionic lotus-root structure, i.e., the element is internally provided with parallel multi-channel structures, so that the porosity and the specific surface area of the biological material are greatly improved, more benefit for adhesion and multiplication of cells and bone formation and vessel formation in a body is achieved, and the application to cell transmission and restoration and regeneration of massive bone defects can be achieved.

Description

technical field [0001] The invention relates to a bioactive scaffold with a bionic lotus root structure, a preparation method thereof and an application for cell transmission and bone repair, belonging to the field of biomaterials. Background technique [0002] Natural animals and plants in nature have evolved special structures and functions through tens of thousands of years of natural selection. Many current studies have imitated the natural structures of organisms to prepare many bionic materials with special structures and unique functions [1-4]. The repair of large bone defects has always been a clinical challenge in modern medicine. Implanting 3D printed porous bio-scaffolds is currently a commonly used method for repairing large bone defects[5,6]. At the same time, studies have shown that the formation of blood vessels in bone repair materials plays an important role in the repair of large bone defects. The initial blood vessels are microchannels composed of endothel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/10A61L27/18A61L27/20A61L27/50A61L27/56
CPCA61L27/042A61L27/10A61L27/105A61L27/18A61L27/20A61L27/50A61L27/56A61L2430/02C08L5/04C08L71/02
Inventor 吴成铁冯春常江邓翠君
Owner 中科硅诺(太仓)生物材料科技有限公司
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