Ultrasonic tissue mimicking phantom as well as preparation method and application thereof

A technology of tissue and ultrasound, applied in application, ultrasound/sonic/infrasonic equipment testing/calibration, ultrasound/sonic/infrasonic diagnosis, etc., can solve the problem of not being able to adjust and control elastic modulus and viscous modulus at the same time, and rarely consider ultrasound Issues such as viscous modulus of imitation tissue phantom

Active Publication Date: 2017-12-08
海斯凯尔(山东)医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the ultrasonic tissue-mimicking phantoms made of gelatin or agar, as well as other common ultrasonic tissue-mimicking phantoms on the market, are standard elastic phantoms. Adjustment controls the modulus of elasticity and viscosity, so there are certain limitations when used as a substitute for human tissue or for device calibration

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  • Ultrasonic tissue mimicking phantom as well as preparation method and application thereof
  • Ultrasonic tissue mimicking phantom as well as preparation method and application thereof

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Embodiment 1

[0042] This embodiment provides an ultrasonic tissue imitation phantom, the preparation method of which comprises the following steps:

[0043] S1. Three polyacrylamides with molecular weights of 36 million, 20 million and 4 million were mixed in a mass ratio of 40.625:50:9.375 to obtain a polyacrylamide mixture with an average molecular weight of 25 million.

[0044] S2. Mix the above-mentioned polyacrylamide mixture with water with a salinity of about 1.2g / L, and then add silica particles with a particle size of about 20 μm, catalyst sodium persulfate, glycerin, preservative potassium sorbate, and mix After uniformity, in the obtained mixed solution, the concentration of polyacrylamide mixture is about 5wt%, the concentration of scatterers is about 3wt%, the concentration of catalyst is about 0.1%, the concentration of glycerin is about 6wt%, and the concentration of preservative is about 1 wt%.

[0045] S3, the above-mentioned mixed solution is poured into the cuboid mold ...

Embodiment 2

[0048] This embodiment provides an ultrasonic tissue imitation phantom, the preparation method of which comprises the following steps:

[0049] S1. Mix three polyacrylamides with molecular weights of 36 million, 20 million and 4 million respectively at a mass ratio of 45.625:40:14.375 to obtain a polyacrylamide mixture with an average molecular weight of 25 million.

[0050] S2. Mix the above-mentioned polyacrylamide mixture with water with a salinity of about 1.2g / L, and then add silica particles with a particle size of about 20 μm, catalyst sodium persulfate, glycerin, preservative potassium sorbate, After mixing evenly, in the obtained mixed solution, the concentration of polyacrylamide mixture is about 7wt%, the concentration of scatterers is about 3wt%, the concentration of catalyst is about 0.1%, the concentration of glycerin is about 8wt%, and the concentration of preservative About 1 wt%.

[0051] S3, the above-mentioned mixed solution is poured into the cuboid mold o...

Embodiment 3

[0054] This embodiment provides an ultrasonic tissue imitation phantom, and the preparation method includes the following steps:

[0055] S1. Mix three polyacrylamides with molecular weights of 38 million, 18 million and 6 million respectively in a mass ratio of 50:45:5 to obtain a polyacrylamide mixture with an average molecular weight of 27.4 million;

[0056] S2. Mix the above polyacrylamide mixture with water with a salinity of about 2.5g / L, and then add silicon carbide particles with a particle size of about 80 μm, catalyst sodium persulfate, glycerin, and preservative potassium sorbate, and mix evenly Finally, in the obtained mixed solution, the concentration of polyacrylamide mixture is about 7wt%, the concentration of scatterers is about 3wt%, the concentration of catalyst is about 0.1%, the concentration of glycerin is about 6wt%, and the concentration of preservative is about 1 wt%.

[0057] S4, the above-mentioned mixed solution is poured into the cuboid mold of 20...

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Abstract

The invention provides an ultrasonic tissue mimicking phantom as well as a preparation method and application thereof. The ultrasonic tissue mimicking phantom is prepared by performing a cross-linking reaction on a mixed liquid of a polyacrylamide mixture, water, scatters and glycerinum. By controlling the components of the polyacrylamide mixture, the elasticity modulus of the ultrasonic tissue mimicking phantom is adjusted and controlled, and by adding glycerinum, the viscous modulus of the ultrasonic tissue mimicking phantom is adjusted and controlled, so that adjustability of the elasticity modulus and the viscous modulus of the ultrasonic tissue mimicking phantom is achieved, and relatively rich possibility of the ultrasonic tissue mimicking phantom in inspection and calibration of ultrasonic imaging instruments is provided.

Description

technical field [0001] The invention relates to an ultrasonic tissue imitation phantom and its preparation method and application, belonging to the technical field of medical polymer materials. Background technique [0002] When performing ultrasonic viscoelasticity imaging testing, it is necessary to have a test sample as a substitute or reference standard for measuring the viscoelasticity of human tissue, so as to facilitate the inspection and calibration of ultrasonic elastic testing equipment and the training of doctors and technicians. This test sample is Ultrasound tissue-mimicking phantom. [0003] The main component of the imitation tissue phantom currently used in B-mode ultrasound imaging and Doppler ultrasound imaging instruments is gelatin or agar. However, most of the ultrasonic tissue-mimicking phantoms made of gelatin or agar, as well as other common ultrasonic tissue-mimicking phantoms on the market, are standard elastic phantoms. Tuning controls the elasti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/26C08K13/02C08K5/053C08K3/34C08K3/26C08K3/36C08K3/04C08J3/24A61B8/00
CPCA61B8/58C08J3/246C08J2333/26C08J2433/26C08K2003/265C08K2201/003C08L33/26C08L2205/025C08L2205/03C08K13/02C08K5/053C08K3/36C08K3/34C08K3/26
Inventor 何琼邵金华孙锦段后利王强
Owner 海斯凯尔(山东)医学科技有限公司
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