Lumen tissue construction body, preparation method and preparation apparatus therefor

Abstract

The invention discloses a lumen tissue construction body, a preparation method and a preparation apparatus therefor. The preparation method for the lumen tissue construction body comprises the steps of enabling a micro-capsule group to be glued on the inner surface of a lumen structure to enable the lumen micro-capsule group to form a biological tissue construction body layer on the inner surface of the lumen structure, wherein the micro-capsule group comprises at least one micro capsule and each micro capsule has biological activity. According to the preparation method, the micro-capsule group is directly glued on the inner surface of the lumen structure to form the biological tissue construction body layer, and the lumen tissue construction body is cultured to obtain the lumen tissue with activity to realize endothelialization of the lumen tissue; in addition, the micro-capsule group is glued on the inner surface of the lumen structure to form the biological tissue construction body layer, so that relative displacement between the formed biological tissue construction body layer and the lumen structure does not occur easily; and therefore, the lumen tissue construction body provided by the embodiment has relatively high biological function and is better suitable for being implanted to the body of a patient.

Description

technical field [0001] The invention relates to the field of artificial biological tissues, in particular to a luminal tissue construct, a preparation method and a preparation device for the luminal tissue construct. Background technique [0002] At present, vascular grafting has been widely used to reconstruct or repair damaged or deformed blood vessels. The usual source of vascular grafts is the patient's own arteries or veins, however, in situations where the patient's own vascular supply is insufficient (eg, the patient has vascular disease or has had prior vascular grafting), a prosthetic vessel is required Or allogeneic blood vessels as a substitute. [0003] In the prior art, common artificial blood vessels are made of polymer fibers (such as nylon, polyester), silk or expanded polytetrafluoroethylene. During vascular grafting, diseased or damaged blood vessels can be replaced with complete artificial blood vessels. Although the use of artificial blood vessels to r...

AI Technical Summary

Problems solved by technology

However, until now, these techniques have been unable to achieve the formation of a complete endothelial cell layer on the inner surface of artificial blood vessels

The cells attached to the inner surface of artificial blood vessels are easy to fall off, difficult to differentiate and survive normally, and do not have better biological functions, which may affect the success rate of blood vessel transplantation and the use effect after transplantation, so it is difficult to meet clinical needs

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