18F-FDG drug synthesis equipment and method for double-batch PET imaging agent

A technology of PET imaging agent and 18F-FDG, which is applied in the fields of pharmaceutical formulation, preparation of sugar derivatives, organic chemical methods, etc., can solve the problems of stability and no synthesis efficiency, and achieve the effect of stable synthesis efficiency

Active Publication Date: 2017-12-15
深圳市保健委员会办公室
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problem in the prior art that there is no double-batch equipment with stable synthesis efficiency, good synthesis effect and simultaneous acid-base hydrolysis, the present invention provides a double-batch PET imaging agent 18 F-FDG drug synthesis equipment and method

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  • 18F-FDG drug synthesis equipment and method for double-batch PET imaging agent
  • 18F-FDG drug synthesis equipment and method for double-batch PET imaging agent
  • 18F-FDG drug synthesis equipment and method for double-batch PET imaging agent

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Embodiment 1

[0024] Such as figure 1 and figure 2 Shown, double batch PET imaging agent 18 F-FDG drug synthesis equipment, including: F-18 nuclide split selection module 1 and double-batch synthesis module;

[0025] The double-batch synthesis module includes two sets of synthesis modules of dual-passage design;

[0026] The synthesis module includes: F-18 negative ion treatment unit 2, 18 O-oxygen-enriched water recyclable unit 3 , automatic sampling unit 4 , reaction unit 5 , heating unit 6 , positive pressure transmission unit 7 and hot and cold air circulation unit 8 .

[0027] The shunt selection module 1 of F-18 nuclide is connected with the F-18 anion processing unit 2 of two sets of synthetic modules respectively; The F-18 anion processing unit 2 is connected with the described 18 The O-oxygen-enriched water recyclable unit 3 is connected to the automatic sampling unit 4; the automatic sampling unit 4 is directly connected to the reaction unit 5 or is connected to the reaction ...

Embodiment 2

[0044] A double-batch PET imaging agent 18 The F-FDG drug synthesis method greatly shortens the reaction time of the synthesis system by improving the catalyst ratio and formulation. K 2.2.2 Solution / K 2 CO 3 The purpose of using the catalyst is to elute and release the radionuclide F-18 captured by the QMA column into the designated reaction system as required. K 2.2.2 Solution / K 2 CO 3 The catalyst is a mixed equilibrium system of organic phase and inorganic phase. Traditionally, the ratio of organic phase to inorganic phase is about 3:1. In the mixed equilibrium system, the proportion of inorganic phase water is relatively high. The improved K 2.2.2 Solution / K 2 CO 3 The purpose of the catalyst is to reduce the proportion of water in the mixed equilibrium system (the proportion of this formula is 5:1) on the premise of ensuring the effect of elution and release of radionuclide F-18, shorten the time of azeotropic water removal and thus shorten the module Overall co...

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Abstract

The invention provides 18F-FDG drug synthesis equipment for a double-batch PET imaging agent. The 18F-FDG drug synthesis equipment comprises a shunt selection module and a double-batch synthesis module of F-18 nuclein; the double-batch synthesis module comprises two sets of synthesis modules respectively adopting a dual channel design; the synthesis module comprises an F-18 negative ion processing unit, an 18O-oxygen-rich water recovery unit, an automatic sampling unit, a reaction unit, a heating unit, a positive pressure transmission unit and a cold and hot air circulation unit. The 18F-FDG drug synthesis equipment provided by the invention is stable in synthetic efficiency and good in synthetic effect and can realize the double-batch hydrolysis of acid and alkali hydrolysis at the same time.

Description

technical field [0001] The invention relates to the technical field of synthesizing positron radiopharmaceuticals in nuclear pharmacy, in particular to a double-batch PET imaging agent 18 F-FDG drug synthesis equipment and method. Background technique [0002] PET / CT imaging has become a new "bright spot" in the development of nuclear medicine. 18 F marked 18 F–FDG can be considered as a valuable radiopharmaceutical of this century, but from 18 F negative ions are synthesized into 18 F-FDG must develop a computer-controlled fully automatic synthesis module. because 18 F negative ions belong to positron radionuclides, when they interact with matter, positron annihilation occurs and two high-energy gamma rays with energy of 511Kev and direction of 180° are released, so from 18 F negative ions are synthesized into 18 F-FDG must develop a fully automatic synthesis module controlled by calculations, and place the synthesizer in a protective shielded thermal chamber that me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H5/02C07H1/00C07B59/00A61K51/04B01J4/00B01J19/24A61K101/02
CPCA61K51/0491B01J4/001B01J19/0013B01J19/2415B01J2219/0006B01J2219/00103C07B59/005C07B2200/05C07H1/00C07H5/02
Inventor 陈立光雷震山邓庆荣李瑜梁明泉陈新亮周必强吕光华
Owner 深圳市保健委员会办公室
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