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Double batch pet imaging agent 18 f-fdg drug synthesis equipment and method

A technology of 18F-FDG and PET imaging agents, which is applied in the fields of pharmaceutical formulations, preparation of sugar derivatives, organic chemical methods, etc., can solve the problems of stability and no synthesis efficiency, and achieve the effect of stable synthesis efficiency

Active Publication Date: 2020-07-17
深圳市保健委员会办公室
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem in the prior art that there is no double-batch equipment with stable synthesis efficiency, good synthesis effect and simultaneous acid-base hydrolysis, the present invention provides a double-batch PET imaging agent 18 F-FDG drug synthesis equipment and method

Method used

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  • Double batch pet imaging agent <sup>18</sup> f-fdg drug synthesis equipment and method
  • Double batch pet imaging agent <sup>18</sup> f-fdg drug synthesis equipment and method
  • Double batch pet imaging agent <sup>18</sup> f-fdg drug synthesis equipment and method

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Embodiment 1

[0024] Such as figure 1 with figure 2 As shown, two batches of PET imaging agent 18 F-FDG drug synthesis equipment, including: F-18 nuclide split selection module 1 and double-batch synthesis module;

[0025] The dual-batch synthesis module includes two sets of synthesis modules with a dual-path design;

[0026] The synthesis module includes: F-18 negative ion processing unit 2, 18 O-oxygen-enriched water recyclable unit 3, automatic sample addition unit 4, reaction unit 5, heating unit 6, positive pressure transmission unit 7 and cold and hot air circulation unit 8.

[0027] The split selection module 1 of F-18 nuclide is respectively connected with the F-18 negative ion processing unit 2 of two sets of synthesis modules; the F-18 negative ion processing unit 2 is respectively connected with the 18 The O-oxygen-enriched water recyclable unit 3 is connected to the automatic sample adding unit 4; the automatic sample adding unit 4 is directly connected to the reaction unit 5 or is con...

Embodiment 2

[0044] A two-batch PET imaging agent 18 The F-FDG drug synthesis method greatly shortens the reaction time of the synthesis system by improving the catalyst ratio and formula. K 2.2.2 Solution / K 2 CO 3 The purpose of the catalyst is to elute and release the radionuclide F-18 captured by the QMA column into the designated reaction system as required. K 2.2.2 Solution / K 2 CO 3 The catalyst is a mixed equilibrium system of organic phase and inorganic phase. The traditional ratio of organic phase to inorganic phase is about 3:1. In the mixed equilibrium system, the proportion of inorganic phase water is higher. Improve K 2.2.2 Solution / K 2 CO 3 The purpose of the catalyst is to reduce the proportion of water in the mixed equilibrium system (the ratio of this formula is 5:1) under the premise of ensuring the effect of eluting and releasing the radionuclide F-18, shortening the time of azeotropic water removal and thus shortening the module Overall synthesis time. Improved K 2.2.2 S...

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Abstract

The invention provides 18F-FDG drug synthesis equipment for a double-batch PET imaging agent. The 18F-FDG drug synthesis equipment comprises a shunt selection module and a double-batch synthesis module of F-18 nuclein; the double-batch synthesis module comprises two sets of synthesis modules respectively adopting a dual channel design; the synthesis module comprises an F-18 negative ion processing unit, an 18O-oxygen-rich water recovery unit, an automatic sampling unit, a reaction unit, a heating unit, a positive pressure transmission unit and a cold and hot air circulation unit. The 18F-FDG drug synthesis equipment provided by the invention is stable in synthetic efficiency and good in synthetic effect and can realize the double-batch hydrolysis of acid and alkali hydrolysis at the same time.

Description

Technical field [0001] The present invention relates to the technical field of positron-type radiopharmaceutical synthesis in nuclear medicine, in particular to a dual batch PET imaging agent 18 F-FDG drug synthesis equipment and method. Background technique [0002] PET / CT imaging has become a new "bright spot" in the development of nuclear medicine. 18 F marked 18 F-FDG can be considered a valuable radiopharmaceutical in this century, but from 18 F negative ion synthesis is 18 F-FDG must develop a fully automatic synthesis module controlled by calculation. due to 18 F negative ion belongs to the positron type radionuclide. When it interacts with the substance, the positron annihilates and releases two high-energy gamma rays with an energy of 511Kev and a direction of 180°. 18 F negative ion synthesis is 18 F-FDG must develop a fully automatic synthesis module controlled by calculations, and place the synthesizer in a shielded hot room with required protection. Since the release...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H5/02C07H1/00C07B59/00A61K51/04B01J4/00B01J19/24A61K101/02
CPCA61K51/0491B01J4/001B01J19/0013B01J19/2415B01J2219/0006B01J2219/00103C07B59/005C07B2200/05C07H1/00C07H5/02
Inventor 陈立光雷震山邓庆荣李瑜梁明泉陈新亮周必强吕光华
Owner 深圳市保健委员会办公室
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