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Production method of pellet type aminophylline bulk drug

A production method, the technology of aminophylline, applied in the direction of raw material extrusion granulation, organic chemistry, chemical/physical/physical chemical fixed reactor, etc., can solve problems such as unsatisfactory product improvement, and achieve high-quality results

Active Publication Date: 2018-01-05
CSPC INNOVATION PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the aminophylline API is in powder form, and its production method can only produce aminophylline powder API, which cannot meet the further improvement of follow-up products

Method used

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  • Production method of pellet type aminophylline bulk drug

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be described in further detail below in conjunction with specific embodiments, but not as a limitation to the present invention.

[0018] 1. Main production equipment

[0019] name

Specifications

The main material

amount)

Ethylenediamine evaporation tank

500L

304

1

Addition tank for the production of aminophylline granular raw material medicine

800L

304

1

Swing pellet machine

YK-160

Stainless steel

1

[0020] 2. The production method of aminophylline granular bulk drug

[0021] 2.1 Distillation and purification of ethylenediamine

[0022] Reduced pressure distillation: turn on the vacuum pump, check that the vacuum system is well sealed, and keep the vacuum degree of the evaporation and return system ≥ 0.06MPa through operation; turn on the condensing equipment, open the steam inlet valve of the external coil of the distillation equipment, and start to process the eth...

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PUM

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Abstract

The invention relates to a production method of a pellet type aminophylline bulk drug, and belongs to the technical field of chemical pharmaceuticals. The method comprises the steps of pressure-reduced distillation and purification through ethylenediamine, mixing and addition reaction, crushing and pelletizing. According to the production method, the original aminophylline production method is optimized and improved; an improved addition device and a pelletizing device are used in match to prepare aminophylline pellets with different types, thus meeting the production demand on different products. According to the method, ethylenediamine liquid is sprayed into a tank body through compressed air; theophylline powder in the tank body is fully in contact with ethylenediamine liquid under theaction of stirring and reacts with ethylenediamine, and thus high-quality aminophylline bulk drug can be quickly prepared.

Description

technical field [0001] The invention relates to a production method of a crude drug, in particular to a production method of an aminophylline granule-type crude drug, and belongs to the technical field of chemical, chemical and pharmaceutical technologies. Background technique [0002] At present, the aminophylline raw material medicine is in powder form, and its production method can only produce aminophylline powdery raw material medicine, which cannot meet the further improvement of follow-up products. In order to better serve the production of follow-up products, it is an urgent problem to seek a method for producing aminophylline granular bulk medicine. Contents of the invention [0003] The technical problem to be solved in the present invention is to overcome the deficiencies of the prior art and provide a production method of aminophylline granular bulk drug, which can produce granular aminophylline bulk drug. [0004] In order to solve the problems of the technol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/18C07D473/08B01J2/20
Inventor 冯志军王坤丽赵旭陈雷马晓津郭少卿
Owner CSPC INNOVATION PHARMA
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