Method for identifying metabolic markers based on heart Yang deficiency syndrome of coronary heart diseases

An identification method and technology for heart-yang deficiency, applied in the field of identification of metabolic markers, can solve the problems of difficult to effectively reveal the relationship between components and therapeutic effects, lack of sufficient sensitivity, etc., and achieve good promotion value, low cost, and pain relief effects.
CN107543873AActive Publication Date: 2018-01-05王喜军
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
王喜军
Publication Date
2018-01-05

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Abstract

The invention discloses a method for identifying metabolic markers based on heart Yang deficiency syndrome of coronary heart diseases. The method solves the problem that the existing clinical diagnosis method of heart Yang deficiency syndrome of coronary heart diseases has poor sensitivity so that the relationship between ingredients in the formula and curative effects is difficult to recover. Themethod comprises 1, carrying out UPLC analysis on n healthy subjects and n patient subjects suffering from heart Yang deficiency syndrome of coronary heart diseases through a UPLC-G2-Si-HDMS method to determine endogenous metabolites in serum samples, 2, carrying out full scanning on the endogenous metabolites in a positive and negative ion mode through a G2-Si-HDMS method to determine endogenousmetabolite structures and 3, identifying blood metabolic biomarkers of subjects suffering from heart Yang deficiency syndrome of coronary heart diseases. The method is used in the field of metabolicmarker identification.
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Description

technical field

[0001] The invention relates to a method for identifying metabolic markers, in particular to an identification method for metabolic markers based on coronary heart disease and heart-yang deficiency. Background technique

[0002] Coronary atherosclerotic heart disease (referred to as coronary heart disease, CHD) is one of the common cardiovascular diseases in clinical practice. The etiology and pathogenesis of coronary heart disease can be briefly summarized as deficiency of heart-yang and endogenous phlegm and blood stasis. Insufficient heart yang and weak blood circulation lead to stagnation of blood circulation and blockage of heart vessels; weakness of heart yang causes yin-cold evil qi to take over the yang position; yin evil is most likely to block the chest yang and cause coronary heart disease. Through the clinical observation of 118 patients with coronary heart disease, Cao Hongxin et al. found that the syndrome of heart-yang deficiency was 62 cases,...

Claims

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