Preparation method for hybridized hydrogel material and application
A hydrogel and hybridization technology, which is applied in the field of preparation of hybrid hydrogel materials, can solve problems such as complex operating conditions, irreversibility, and undisclosed methods of constructing hybrid supramolecular hydrogel materials through electrostatic interactions
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Embodiment 1
[0079] 1. Raw materials
[0080] 1.1 Synthesis of macromolecular initiator NH 2 -Phe-PEG 227 -Phe-NH 2 raw material
[0081]
[0082] 1.2 Raw materials for the synthesis of Lys(Z)-NCA
[0083] H-Lys(Z)-OH 1g, 3.57mmol
[0084] Triphosgene 0.42g, 1.43mmol
[0085] 1.3 Raw materials for the synthesis of polylysine-polyethylene glycol-polylysine
[0086] NH 2 -Phe-PEG 227 -Phe-NH 2 1g, 0.1mmol
[0087] Lys(Z)-NCA 0.31g, 1mmol
[0088] 1.4 Raw materials for the synthesis of hybrid hydrogels
[0089] The charge concentrations of the positively charged amino groups of polylysine and the negatively charged phosphate groups in the DNA structure are respectively controlled at 20mM, and the charge molar ratio of the triblock copolymer to protist DNA is 1:16.
[0090] 2. Preparation method
[0091] 2.1 Synthesis of phenylalanine-terminated polyethylene glycol (NH 2 -Phe-PEG 227 -Phe-NH 2 )
[0092] Phenylalanine-terminated polyethylene glycol (NH 2 -Phe-PEG 227 -Ph...
Embodiment 2
[0113] 1. Raw materials
[0114] 1.1 Synthesis of macromolecular initiator NH 2 -Phe-PEG 227 -Phe-NH 2 raw material
[0115]
[0116] 1.2 Raw materials for the synthesis of Lys(Z)-NCA
[0117] H-Lys(Z)-OH 0.8g, 2.85mmol
[0118] Triphosgene 0.339g, 1.14mmol
[0119] 1.3 Raw materials for the synthesis of polylysine-polyethylene glycol-polylysine
[0120] NH 2 -Phe-PEG 227 -Phe-NH 2 0.8g, 0.08mmol
[0121] Lys(Z)-NCA 0.49g, 1.6mmol
[0122] 1.4 Raw materials for the synthesis of hybrid hydrogels
[0123] The charge concentrations of the positively charged amino groups of polylysine and the negatively charged phosphate groups in the DNA structure are respectively controlled at 20mM, and the charge molar ratio of the triblock copolymer to protist DNA is 1:10.
[0124] 2. Preparation method
[0125] 2.1 Synthesis of phenylalanine-terminated polyethylene glycol (NH 2 -Phe-PEG 227 -Phe-NH 2 ) method with embodiment 1.
[0126] 2.2 Synthesis of Lys(Z)-NCA
[012...
Embodiment 3
[0138] 1. Raw materials
[0139] 1.1 Synthesis of macromolecular initiator NH 2 -Phe-PEG 227 -Phe-NH 2 raw material
[0140]
[0141] 1.2 Raw materials for the synthesis of Lys(Z)-NCA
[0142] H-Lys(Z)-OH 1.5g, 5.35mmol
[0143] Triphosgene 0.635g, 2.14mmol
[0144] 1.3 Raw materials for the synthesis of polylysine-polyethylene glycol-polylysine
[0145] NH 2 -Phe-PEG 227 -Phe-NH 2 1.2g, 0.12mmol
[0146] Lys(Z)-NCA 0.294g, 0.96mmol
[0147] 1.4 Raw materials for the synthesis of hybrid hydrogels
[0148] The charge concentrations of the positively charged amino groups of polylysine and the negatively charged phosphate groups in the DNA structure are respectively controlled at 20mM, and the charge molar ratio of the triblock copolymer to protist DNA is 1:20.
[0149] 2. Preparation method
[0150] 2.1 Synthesis of phenylalanine-terminated polyethylene glycol (NH 2 -Phe-PEG 227 -Phe-NH 2 ) method with embodiment 1.
[0151] 2.2 Synthesis of Lys(Z)-NCA
[0...
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